摘要
目的:探讨促脑血管疾病的一些常见危险因素与帕金森病(Parkinson's disease,PD)之间的关系。方法:对在重庆医科大学附属第一医院就诊的PD患者及健康体检者抽血检测血糖、低密度脂蛋白胆固醇(Low density lipoprotein cholesterol,LDL-C)及同型半胱氨酸(Homocysteic acid,Hcy),同时行颈动脉彩超了解颈总动脉内膜中层厚度(Intima-media thickness of carotid artery,IMT),对PD患者进行帕金森病统一评定量表(Unified Parkinson's disease rating scale,UPDRS)评分。对PD组和对照组检查结果进行统计学分析,并将可能与PD发病有关的因素纳入相关分析。结果:PD组血糖水平高于对照组(P<0.05);Hcy水平高于对照组(P<0.01);PD组LDL-C水平低于对照组(P<0.05);IMT值小于对照组(P<0.001)。Spearman相关分析显示Hcy与PD发病呈正相关,LDL-C、IMT与PD发病呈负相关,血糖与PD发病无明显相关性。结论:本实验结果提示高Hcy是PD发病的危险因素;实验证实PD病人LDL-C、IMT明显低于对照组,提示患动脉粥样硬化的几率相对较小。
Objective：To investigate the relationship between some common risk factors of the cerebralvascular diseases and PD.Methods：Case-control study was carried out.Blood glucose,low density lipoprotein cholesterol（LDL-C）and homocysteic acid（Hcy） levels were detected by routine methods.The intima-media thickness（IMT）of carotid artery was measured by color Doppler ultrasound.The PD patients were graded by Unified Parkinson＇s Disease Rating Scale（UPDRS）.Results：The blood glucose and Hcy in PD patients were higher than that in control group,and the LDL-C,IMT of carotid artery in PD were lower than that in control group.The Hcy was positively related to risk of PD,while IMT of carotid artery and LDL-C were negatively related to risk of PD by Spearman analysis.Conclusion：The Hcy level is a risk factor of PD.The LDL-C and IMT of carotid artery in PD patients were lower than that in control group,which suggests that the probability of PD patients who suffer from atherosclerosis is small.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第4期561-563,共3页
Journal of Chongqing Medical University
