摘要
目的:探讨生长激素(GH)、胰岛素样生长因子-I(IGF-I)在乳腺癌患者血清中的表达情况及其临床意义。方法:采用酶联免疫吸附试验(ELISA)检测乳腺癌组、乳腺良性病变组、对照组的血清GH、IGF-I水平。结果:①乳腺癌组、乳腺良性病变组和对照组血清GH、IGF-I表达差异无统计学意义(P>0.05);②血清IGF-I表达乳腺癌组绝经前高于绝经后(P=0.005);③GH表达与肿块大小和雌激素受体(ER)表达有关(P=0.002,P=0.006),IGF-I表达和肿块大小有关(P=0.010)。④IGF-I表达与肿块>2cm呈负相关(r=-0.393,P=0.022),血清GH、IGF-I表达与乳腺癌年龄和ER表达无相关关系(P>0.05)。结论:血清GH、IGF-I的表达可能与乳腺癌增殖和进展有关。
Objective：To detect serum growth hormone（GH）and insulin-like frowth-factor-I（IGF-I）levels in patients with breast cancer and to discuss the clinical significance.Methods：The levels of serum GH and IGF-I in samples were determined by ELISA.Results：The level of serum GH or IGF-I between the premenopausal and postmenopausal patients in the breast cancer group,benign lesion group and control group were no statistical difference.The level of serum IGF-I in premenopausal patients with breast cancer was higher than that in postmenopausal ones（P=0.005）.The level of serum GH was associated with the tumor size and the estrogen receptor expression（P=0.002 and 0.006,respectively）.The level of serum IGF-I was associated with the tumor size（P=0.010）.Serum IGF-I was negtive correlated with tumor size when the diameter of tumor was larger than 2 cm（r=-0.393,P=0.022）.There was no correlation among the level of GH or IGF-I and age or estrogen receptor expression in breast cancer patients.Conclusion：It indicates that there is a good relation between serum level of GH or IGF-I and the proliferation and progression of breast cancer.
出处
《广西医科大学学报》
CAS
2010年第2期216-219,共4页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目(No.桂科自0640110)
