摘要
目的探讨糖尿病肾病与甲状腺激素水平的关系。方法搜集我院内分泌科2005年6月～2008年5月住院的2型糖尿病病人共747例,根据尿微量白蛋白排泄率分为无糖尿病肾病组(UAER≤20 ug/min),轻度肾病组(20<UAER<200 ug/min)和重度肾病组(UAER≥200 ug/min),比较甲状腺素水平;并以糖尿病肾病作为自变量,对危险因素作Logistic回归分析。结果糖尿病肾病组与无肾病组相比,年龄,病程,收缩压,舒张压,糖化血红蛋白,空腹血糖,总胆固醇,低密度脂蛋白,甘油三酯,均明显升高。甲状腺激素水平FT3,FT4降低,差异有统计学意义,且随糖尿病肾病程度加重而降低,TSH无明显变化。以糖尿病肾病作为因变量进行Logistic回归显示低FT3是糖尿病肾病的独立危险因素。结论糖尿病肾病患者存在不同程度的甲状腺激素水平降低,监测甲状腺功能变化,有助于评估糖尿病肾病病情变化。
Objective To evaluate the correlation between diabetic nephropathy and serum thyroid hormone in type 2 diabetes mellitus patients. Methods 747 inpatient cases with type 2 DM from endocrinology department were collected from June 2005 to Mary 2008. They were divided into three groups according to the level of UAER： non diobetic nephropathy group （UAER≤20 ug/min）, mild kidney disease group（20〈UAER≤200 ug/min） and severe kidney disease group （UAER〉200 ug/min）. And the last two groups are also called diabetic nephropathy group. Serum thyroid hormone was monitored. The data was analyzed by multiple logistic regression analysis. Results The risk factors including age, course ,systolic blood pressure, despotic blood pressure, HbAlc ,fasting glucose, total cholesterol, triglycerides, low - density lipoprotein are significantly higher in diabetic nephropathy group than non diabetic nephropathy group. FT3, FT4 in diabetic nephropathy group are significantly lower than non diabetic nephropathy group. FT3 and FT4 decreased with the progression of diabetic nephropathy. TSH has no change. Conclusion Patients with diabetic nephropathy has certain degrees of hypothyroidism. It will contribute to assess the condition of diabetic nephropathy to monitor thyroid function changes.
出处
《湖南中医药大学学报》
CAS
2010年第4期13-17,共5页
Journal of Hunan University of Chinese Medicine
关键词
2型糖尿病
糖尿病肾病
甲状腺激素
type2 diabetes mellitus （2-DM）
diabetic nephropathy （ DN ）
thyroid hormone
