摘要
目的探讨丙戊酸镁治疗躁狂症的疗效及副反应。方法用丙戊酸镁与碳酸锂对照治疗躁狂症１１８例。采用躁狂量表（ＢＲＭＳ）、临床疗效总评量表（ＣＧＩ）及副反应量表（ＴＥＳＳ）评定疗效及副反应。结果两组疗效近似，治疗后ＢＲＭＳ总分减分率及各因子分明显低于疗前。丙戊酸镁的副反应以口干、恶心、心动过速为主，与碳酸锂近似，镇静作用较碳酸锂弱。结论丙戊酸镁对躁狂症有较好的疗效。
Objective The purpose of this paper was to study the therapeutic effects and side-effects of magnesium valporate in the treatment of mania.Methods The Bech-Rafaelsen mania Rating Scale(BRMS),the Clinical Global IMPression Scale(CGI) and the Treatment Emeragent symptoms Scale(TESS) were used to measuring the 118 inpatients with diagnosis of mania in accordance with CCMD-2-R.The subjects were randomlly assigned into the magnesium valporate group(n=60) and the lithium carb onate group(n=58).Results The results showed that therapeutic effiacy of magnesium valporate was compared to that of lithium carbonate,the profiles and total scores in both groups significant decreasing as compared with the baseline before the treatment.The main side effects of magnesium valporate were similiar to those of lithium carbonate,these side effects included dry mouth、nauseating and tachycardia.The findings indicated the magnesium valproate is effective in the treatment of mania.
出处
《四川精神卫生》
1999年第1期27-28,共2页
Sichuan Mental Health
