摘要
目的:观察氯沙坦和氨氯地平对肾移植患者24h尿蛋白及血、尿转化生长因子β1的影响。方法:选择佛山市第一人民医院初次肾移植后伴轻、中度高血压(收缩压140～170mmHg,舒张压85～100mmHg,1mmHg=0.133kPa)患者40例,男23例,女17例,年龄(38.6±19.2)岁,随机数字表法分为氯沙坦组和氨氯地平组,每组20例。氯沙坦组口服氯沙坦50mg/d治疗,氨氯地平组口服氨氯地平5mg/d治疗,要求患者血压控制在130/80mmHg以下,治疗6个月后检测血压、肾功能、24h蛋白尿与血、尿转化生长因子β1水平。结果:40例患者均进入结果分析。患者用药后收缩压、舒张压均显著下降(P<0.05),治疗6个月后,收缩压、舒张压均降至正常水平(P<0.01)。治疗期间,2组血压下降值及平均动脉压比较差异无显著性意义(P>0.05)。2组治疗总有效率比较差异无显著性意义(P>0.05)。2组患者治疗前后血尿素氮、肌酐和血尿酸差异无显著性意义(P>0.05)。治疗6个月后,氯沙坦组24h尿蛋白与血、尿转化生长因子β1水平较治疗前显著下降(P<0.05),氨氯地平组24h尿蛋白与血、尿转化生长因子β1水平无明显变化(P>0.05)。氯沙坦组24h尿蛋白与血、尿转化生长因子β1水平均低于氨氯地平组(P<0.05)。结论:氯沙坦与氨氯地平均可有效地控制肾移植患者的高血压状态,但氯沙坦可明显降低肾移植患者24h尿蛋白与血、尿中转化生长因子β1水平,氨氯地平的作用不明显。
OBJECTIVE：To investigate the effect of Losartan and Amlodipine on serum and urine transforming growth factor-β1 in patients undergoing kidney transplantation.METHODS：A total of 40 patients with mild or moderate hypertension （systolic pressure 140-170 mm Hg,and diastolic pressure 85-100 mm Hg,1 mm Hg=0.133 kPa） following primary kidney transplantation were selected from First People＇s Hospital of Foshan,including 23 males and 17 females aged （38.6±19.2） years.They were randomly divided into two groups （n=20）：Losartan group （oral administration 50 mg per day） and Amlodipine group （oral administration 5 mg per day）.The blood pressure of patients should be controlled below 130/80 mm Hg.The blood pressure,renal function,24 h-proteinuria,serum and urine transforming growth factor-β1 6 months after medication were observed.RESULTS：A total of 40 patients were included in the final analysis.The systolic pressure and diastolic pressure of patients were decreased after administration （P〈 0.05） and decreased to normal levels 6 months after administration （P〈0.01）.During treatment,there were significant differences in blood pressure decrease and mean arterial pressure between two groups （P〉.05）.No difference was found in total efficacy between two groups （P〉0.05）.In addition,blood urea nitrogen,creatinine,and blood uric acid did not significantly alter after treatment in two groups （P〉0.05）.After 6 months of treatment,24 h-proteinuria,serum and urine transforming growth factor-β1 in Losartan group were significantly decreased compared with before treatment （P 〈0.05）,while no obvious changes were found in Amlodipine group （P〉0.05）.The 24 h-proteinuria,serum and urine transforming growth factor-β1 in Iosartan group were significantly less than Amlodipine group （P〈0.05）.CONCLUSION：Both Losartan and Amlodipine effectively controlled hypertension of patients following kidney transplantation,but Losartan significantly decreased 24 h-proteinuria,ser
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第53期10541-10544,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
