摘要
目的:合成氨基噻唑类衍生物并研究其抗流感病毒活性。方法:以氨基噻唑类化合物为母核,合成一系列神经氨酸酶抑制剂,通过在体方法检测其对流感病毒的抑制活性。结果与结论:合成了6个新化合物,其中部分化合物具有一定的抗流感病毒活性。
Objective：To synthesize aminothiazole and its analogs,and evaluate their anti-influenza virus activity.Methods：A series of chemical compounds were synthesized from aminothiazole,and the neuraminidase inhibitory activities of these compounds were tested.Results and Conclusion：Six new compounds have been synthesized;some of them have anti-influenza virus activity.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第9期801-804,共4页
Chinese Journal of New Drugs
关键词
氨基噻唑
神经氨酸酶抑制剂
流感病毒
合成
aminothiazole
neuraminidase inhibitors
influenza virus
synthesis
