摘要
目的:在293例有三唑仑滥用史的多药滥用者中评价三唑仑的药物依赖性.方法:参考苯二氮(?)类戒断症状量表(BWSQ),自拟三唑仑戒断症状量表(TWSQ)评价三唑仑的身体依赖性;采用成瘾研究中心量表(ARCI-CV)评价三唑仑的精神依赖性;采用视类比量表(VAS)评价对滥用三唑仑、海洛因的渴求.结果:根据TWWQ,三唑仑各项戒断症状分值为0.06～2.32;根据ARCI,测量药物欣快效应的MBG分量表、测量镇静效应的PCAG分量表和测量拟精神病效应的LSD分量表的平均分值分别是8.07±3.46,6.47±2.26和4.77±2.61(F=9.72,P<O.01);41.10%的受试者对三唑仑有不同程度的渴求(X^2=206.8,P<0.01).结论:三唑仓在药物滥用中具有较强的药物滥用潜力.
To assess the drug dependence and abuse liability of triazolam in 293 subjects with history of triazolam abuse. 193 subjects were heroin addicts and the other were DUE or doalantin addicts. Physical dependence of triazolam was assesed by using Triazolam Withdrawal Symptom Questionnaire (TWSQ); psychic dependence was assessed by association test of Addiction Research Center Inventory-Chinese Version (ARCI-CV); the degree of craving experienced for triazolam and heroin was self-reported on Visual Analogue Scale (VAS). Our results showed that the score of TWSQ was 0.06~2.32; the scores used for identifying euphoric effect (MBG), sedative effect (PCAG) and psychotomimetic effect (LSD) were 8.67, 6.47 and 4.77 respectively (F=9.72, P<0.01). 41.1% of triazolam abusing subjects had craving experienced for triazolam of different degrees (X^(2) = 206.8, P<0.01). It is concluded that triazolam produced high abuse potential among opiate. DHE and dolantin addicts.
出处
《药物流行病学杂志》
CAS
1999年第1期5-7,22,共4页
Chinese Journal of Pharmacoepidemiology
关键词
三唑仑
药物依赖性
药物滥用
流行病学
Triazolam
Substance abuse
Substance dependence
Multi-drug abuse
