摘要
目的:研究神经营养因子(NTFs)及其受体在前列腺癌中的表达。方法:采用免疫印迹法检测35例前列腺癌患者前列腺组织中神经生长因子(NGF)、脑源性神经营养因子(BDNF)以及其受体TrkA、TrkB、p75的表达,并以10例意外死亡年轻人正常前列腺组织中表达水平作对照。结果:与对照组相比,癌组织中NGF表达下降,而BDNF表达上调,差异均具有显著性(P<0.01);另外,癌组织中p75表达下调,但TrkA、TrkB表达均上调,且差异都具有显著性(P<0.05)。结论:NGF、BDNF及其受体表达变化与前列腺癌发生发展有关,可作为诊断前列腺癌的参考指标。
Objective：To investigate the expressions of neurotrophic factors（NTFs） and their receptors in prostate cancer. Methods：We detected the expressions of the nerve growth factor（NGF）,brain-derived neurotrophic factor（BDNF）,and their receptors TrkA,TrkB and p75 in 35 specimens of prostate cancer by Western blotting,and included 10 specimens of normal prostate tissue from young males that died accidentally.Results：Compared with the control group,the expressions of NGF and p75 were significantly decreased（P〈0.01）,while those of BDNF,TrkA and TrkB significantly increased in prostate cancer（P〈0.05）.Conclusion： The changes in the expressions of NTFs and their receptors were related with the pathogenesis and progression of prostate cancer, which may be considered as reference indexes for the diagnosis of the disease.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第2期129-131,共3页
National Journal of Andrology
