摘要
目的:探讨他汀预处理对经皮行冠状动脉介入治疗(PCI)患者随访期间的主要心脑血管事件(MACCE)发生的影响。方法:回顾性分析2003年6月至2005年9月北京安贞医院行PCI手术患者3893例,根据是否接受他汀预处理分为他汀预处理组(n=3361)和非他汀预处理组(n=532),比较两组一般的临床特征和人口学资料并进行随访,采用多因素COX回归分析他汀预处理对PCI患者的随访期间的MACCE的影响的独立危险因素。结果:他汀预处理不能降低随访期间病死率和总MACCE事件(1.7%vs.1.3%;12.9%vs.8.9%,P>0.05),在校正年龄、性别等临床基线数据后,COX回归分析显示:他汀预处理组与非他汀预处理组比较,PCI患者随访期间死亡风险RR值为1.168(95%CI0.33～4.136,P=0.810)。结论:他汀预处理不能够降低随访期间总心脑血管事件和住院期间病死率的风险,随访期间死亡事件的独立的预测因素为年龄、射血分数<50%、三支冠状动脉病变、女性、血肌苷水平。
Objective To investigate the effect of preoperative statin therapy on the incidence of major adverse cardiac and cerebrovascular events （MACCE） during follow-up after percutaneous coronary intervention （PCI）. Methods The data on 3 893 patients undergoing PCI （3 36t receiving preoperative statin therapy and 532 receiving no statin） between June 2003 and September 2005 were retrospectively analyzed. The clinical features and demographic data were compared between the two groups.The independent risk factors for MACCE after pretreatment with statin were analyzed by multivariate COX regression. Results As compared with non-statin group, preoperative statin therapy did not lower the mortality and the overall MACCE during follow-up （1.7% vs.l.3% and 12.9% vs. 8.9%, P 〉 0.05）. After adjustment of age and sex, the hazard ratio for mortality was 1.168 （95% C1 0.33 ～ 4.136, P = 0.810）. Conclusions Preoperative statin therapy does not lower the risks of mortality and the incidence of major adverse cardiac and cerebrovascular events during follow-up after PCI. The independent prognostic parameters for the mortality are age, LVEF less than 50%, triple-vessel disease, female and blood Cr levels.
出处
《实用医学杂志》
CAS
北大核心
2010年第8期1335-1338,共4页
The Journal of Practical Medicine
关键词
心血管疾病
他汀预处理
经皮冠状动脉介入术
主要心脑血管疾病
Cardiovascular diseases
Preoperative statin therapy
Percutaneous coronary intervention
Major adverse cardiac and cerebrovascular events
