摘要
目的总结未经治疗的儿童弥漫性脑桥胶质瘤的自然史。方法回顾性分析6例经MRI影像学检查证实为弥漫性脑桥胶质瘤病儿的临床资料。其中复视4例,展神经麻痹3例,上睑上抬无力、伸舌偏和眼震各1例,共济失调3例,单侧肢体无力3例,单侧肢体麻木和单侧病理征各1例。随访2～5个月。结果病儿均于发病后6个月内死亡,发病至死亡的时间间隔为3.0～6.0个月,平均4.3个月;就诊至死亡的时间间隔为2.0～5.0个月,平均3.4个月。结论弥漫性脑桥胶质瘤病儿的预后极差,未经治疗者生存期为3～6个月。
Objective To summarize the natura l history of diffuse pontine gliomas without receiving any treatment in children.Methods The clinical data of 6 children with diffuse pontine gliomas which were confirmed by MR imaging were analyzed retrospectively.Diplopia was found in 4 cases,abducens paralysis in 3,upper eyelid weakness,crooked tongue and nystagmus in 1 each,ataxia in 3,unilateral weakness of extremity in 3,limb numbness and positive pyramidal signs in one side in 1 each.The follow up period was 2 to 5 months.Results All the patients died within 6 months after illness onset.Time intervals from onset to death and from visiting to death were 3.0 to 6.0 and 2.0 to 5.0 months,with a mean interval of 4.3 and 3.4 months,respectively.Conclusions The prognosis of diffuse pontine gliomas in children is unfavourable and the survival period of patients is 3 to 6 months without any treatment.
出处
《中国微侵袭神经外科杂志》
CAS
北大核心
2010年第4期155-157,共3页
Chinese Journal of Minimally Invasive Neurosurgery
基金
国家自然科学基金(编号:30772237)
