摘要
目的探寻临床治疗小阴茎的有效治疗办法及其选择用药的依据。方法按照小阴茎诊断标准选择病例，分为HCG组（肌注HCG，每次1000IU，每周2次，连用6周）和T组（每日外用睾酮霜2次），并于治疗前后测定阴茎长度、睾丸大小及性激素水平等以观察其疗效及影响。结果阴茎长度测量：用药前两组阴茎长度比较无显著差异（P〉0．05），而用药后两组均有显著增长（P〈0．05），但两组用药后增加值比较无显著差异（P〉0．05）。睾丸体积测量：用药前两组睾丸体积比较无显著差异（P〉0．05），但HCG组用药后有显著增长（P〈0．05），而睾酮组用药后睾丸体积仅稍有增长（P〉0．05）。激素水平测定：除HCG组用药前后睾酮水平比较有显著性差异（P〈0．05）外，其他各检测指标均无明显变化。疗效：HCG组中7例显效、5例有效、4例无效；T组中6例显效、7例有效、2例无效。两组比较疗效无显著性差异（P〉0．05）。结论肌注HCG和外用睾酮霜治疗儿童小阴茎均可使阴茎明显的增长，且对性激素水平无明显干扰，并与患儿年龄大小无关。但外用睾酮霜更为方便实用，在为使睾丸得到同步增长时也可首选HCG治疗。两药治疗无效时应想到雄激素抵抗综合症可能。
Objective To investigate the efficacy of HCG and transdermal testosterone therapy for the patients with micropenis. Methods Pediatric patients, who were diagnosed with micropenis, were divided into HCG and testosterone（T） group according to the treatments they received. In group HCG, 1000IU HCG was administered to patients by intramuscular injection twice a week for six weeks. In group T, testosterone cream was applied transdermally twice a day for 2 months. Penile length, testicular size, and sex hormone levels were measured during follow-up. Results No significant differences of penile length and testieular volume was noted between these 2 groups before medication initiation （P〉0.05）. After treatment, penile length increased in both groups （P〈0. 05）, but no significant differences of penis length was found between the two groups （P〉0.05）. After treat- ment, testicular volume markedly increased in HCG group （P〈0. 05）, and increased slightly in T group. Testosterone level increased significantly in HCG group （P〈0. 05）, the other hormones didn＇t change significantly in both groups. In group HCG, the treatment was significantly effective on 7 patients, effective on 5, and non effective on 4. In group T, the treatment was significantly effective on 6 patients, effective on 7, and non-effective on 2. There was no significant difference of therapeutic ef ficacy between the two groups （P〉0. （75）. Conclusions HCG and trandermal testosterone therapy can promote the growth of micropenis in different age without interfering Sex hormone levels. Transdermal testosterone therapy is convenient and practical. HCG therapy could be the first choice to increase the testicular volume. Androgen resistance syndrome should be considered when both of the two treat ments are ineffective.
出处
《中华小儿外科杂志》
CSCD
北大核心
2010年第4期265-268,共4页
Chinese Journal of Pediatric Surgery
关键词
阴茎
人绒毛膜促性腺激素
睾酮
Penis
Human chorionic gonadotropin
Testosterone
