摘要
目的观察翡翠贻贝多糖(PVPS)对荷瘤小鼠肿瘤生长及免疫功能的影响。方法建立小鼠移植性S180实体瘤模型,观察PVPS对荷瘤小鼠的抑瘤率及对T淋巴细胞增殖能力、白介素2(IL-2)等指标的影响。结果 PVPS可明显抑制荷瘤小鼠S180实体瘤的生长(P<0.05 orP<0.01),提高T淋巴细胞增殖能力和IL-2的产生(P<0.01)。结论 PVPS可显著抑制荷瘤小鼠肿瘤的生长,并能增强荷瘤小鼠的免疫功能。
Objective To study the effect of Perna viridis polysaccharides （PVPS）on the anti-tumor and immune function of tumor-bearing mice. Methods Establish the mice model of transplatable S180 solid tumor and observe the effect of PVPS on the inhibition ratio of tumor, the proliferating activity of T lymphocytes and the level of IL-2 of the tumor-bearing mice. Results The PVPS significantly inhibit the growth of S180 tumor in mic （P 〈 0.05 or P 〈 0. O1 ）. In addition, PVPS could significantly enhance the proliferating activity of T lymphocytes and the level of IL-2 （ P 〈 0. 01 ）. Conclusion The PVPS can inhibit the growth of tumor and in- crease the immunological function of tumor-bearing mice.
出处
《中国现代药物应用》
2010年第9期15-16,共2页
Chinese Journal of Modern Drug Application
基金
广东省自然科学基金(项目编号:5011588)
湛江市科技攻关项目(项目编号:2008C03015)
关键词
翡翠贻贝
多糖
抗肿瘤
免疫功能
Perna viridis
Polysaccharide
Anti-tumor
Immune function
