摘要
[目的]探讨血清胆碱酯酶（ChE）水平在危重症患者病情预判中的作用以及与急性生理学与慢性健康状况评分Ⅱ（APACHEⅡ）评分的关系。【方法】对收入急诊重症监护病房（EICU）的136例危重患者（A组）的入院24h内的血清ChE水平进行测定，并与30例正常人（B组）的血清ChE水平进行对比分析。同时对A组136例患者依照APACHEⅡ评分分值的高低分成三组（〈15分组、15～20分组、〉20分组），比较三组间血清ChE水平的差异。并比较死亡病例的ChE与APACHEⅡ的关系。【结果】①A组血清ChE平均水平较B组明显降低（P〈0．01）。②A组血清ChE水平与其APACHEⅡ评分的分值成负相关（r=0．2251，P〈0．01）：病情越危重，APACHEⅡ评分的分值越高且死亡率越高，相对应血清ChE的水平越低（P〈0．01）。【结论】血清胆碱酯酶水平是反映危重症病情严重性及评价预后的一项重要临床参考指标，两者联合检测效价更高。
[Objective] To explore the role of serum cholinesterase（ChE） level in the evaluation of the prognosis of critical care patients and its relationship with acute physiology and chronic health evaluation Ⅱ （A PACHE Ⅱ ）. [Methods] The levels of serum ChE in 136 critical care patients（group A） and 30 normal individ uals（group 13） were detected with colorimetric method. APACHE Ⅱ was determined for each patient during the first 24h in the emergency intensive care unit（EICU）. All patients were divided into three groups based on their APACHE Ⅱ scores and were further divided into survival subgroup and death subgroup based on their clinical outcome. The levels of serum ChE among three groups and two subgroups were compared. The relationship between ChE levels and APACHE Ⅱ scores was analyzed. [Results]Serum ChE level in group A was markedly lower than that in group B （ P 〈0.01）. Serum ChE level in group A was negatively correlated with APACHE Ⅱ score（r= -0. 2251, P 〈0.01）. [Conclusion]Serum ChE level can reflect the critical care patient＇ s condition and the prognosis. Combined determination of serum ChE with APACHE Ⅱ scores will be more accurate for this.
出处
《医学临床研究》
CAS
2010年第4期579-581,共3页
Journal of Clinical Research
