摘要
对苯二酚和3,4-二氟苯腈通过选择性单醚化反应合成中间体4-(4-氰基-2-氟苯氧基)苯酚,再与(S)-2-(4-甲基苯磺酰氧基)丙酸丁酯反应得到氰氟草酯,所得产物经过MS和1HNMR确证。在较佳的反应条件下,反应总收率为82.2%,氰氟草酯的化学纯度为98.6%,ee值为98.0%。
Herbicide cyhalofop-butyl was synthesized from the SN2 reaction of （S）-butyl 2-（4-toluenesulfonyloxy） lactate with the intermediate 4-（4-cyano-2-fluorophenoxy）phenol, which was obtained by the selective etherification of hydroquinone with 3,4-difluorobenzonitrile. The structure of the target compound was confirmed by MS and ^1H NMR. Under the optimal conditions, the chemical purity and the optical purity of the product were up to 98.6 and 98.0% ee, respectively, with the total yield being 82.2%.
出处
《农药》
CAS
北大核心
2010年第5期329-331,337,共4页
Agrochemicals
关键词
氰氟草酯
合成
3
4-二氟苯腈
对苯二酚
cyhalofbp-butyl
synthesis
3,4-difluorobenzonitrile
hydroquinone
