摘要
以钙基蒙脱土为原料,采用微波-力化学法制备钠基蒙脱土(MMT)。采用溶液离子交换法制备盐酸西替利嗪(CTH/MMT)纳米复合物,研究了MMT对CTH的吸附规律。利用XRD、FTIR、TG等分析了CTH/MMT复合物的结构。通过体外人工模拟胃、肠液中的释放实验表征了CTH/MMT的缓释效果、缓释机制及其动力学。结果表明,CTH插层于MMT层间,层间距由1.25 nm增至2.13 nm。MMT对CTH插层吸附等温线符合Freundlich吸附等温方程,其吸附动力学符合二级动力学方程。体外的缓释试验表明,CTH/MMT具有良好的缓释效果,MMT可作为盐酸西替利嗪的控释载体材料。
Na-modified Ca-montmorillonite（Ca-MMT） was successfully prepared by a microwave-mechanochemistry technique.A new composite based on drug cetirizine hydrochloride（CTH） and Na-montmorillonite（Na-MMT） was prepared by the ion-exchange method,and the adsorption characteristics of CTH onto Na-MMT were evaluated.Through Fourier transformed infrared（FTIR） and X-ray diffraction（XRD） analyses,the structure of the resulted CTH/MMT composite was confirmed.The in vitro drug release research of the CTH/MMT composite in both artificial simulated gastric juice（ASGJ） and artificial simulated intestinal juice（ASIJ） was used to study the efficiency,mechanism and kinetics of the drug release process.The results show that CTH intercalates in Na-MMT,and the interlayer spacing increases from 1.25 nm to 2.13 nm.The adsorption kinetics is found to follow the pseudo-second-order kinetic model.The adsorption equilibrium data corresponds to Freundlich model.In vitro experiments show that CTH/MMT has a good sustained-release effect,and MMT can be used as a controlled-release carrier for CTH.
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2010年第1期43-50,共8页
Acta Materiae Compositae Sinica
关键词
蒙脱土
盐酸西替利嗪
微波
吸附
缓释
动力学
montmorillonite
cetirizine hydrochloride
microwave
adsorption
sustained-release
kinetics
