摘要
目的探讨原发性甲状腺功能减退致垂体增生的诊断和处理原则。方法结合文献回顾性分析4例原发性甲状腺功能减退致垂体增生的临床资料。结果4例均表现为促甲状腺激素（TSH）及催乳素（PRL）增高，V13及FT4减少，MRI示垂体增大，甲状腺素替代治疗2—4个月后，垂体恢复正常，TSH及PRL水平亦恢复正常。结论原发性甲状腺功能减退致垂体增生具有影像学特征，结合临床可明确诊断。治疗首选甲状腺素实验性替代治疗，而不宜行手术治疗。
Objective To discuss the diagnosis and management of pituitary hyperplasia due to primary hypothyroidism. Methods To report four cases with pituitary hyperplasia due to primary hypothyroidism and review literatures. Results All four cases with both elevated thyrotrophin stimulating hormone （TSH） and prolactin（PRL） and low thyroid hormone values were studied. Pituitary mass was revealed by MR1 imaging. After two to four months of thyroxine substitution therapy, the manifestation of hypothyroidism disappeared, TSH and PRL became normal, pituitary gland recovered to normal size. Conclusion Pituitary hyperplasia due to hypothyroidism has some endocrine examination and MR1 characteristics. Its diagnosis can be made according to the examination combined with clinical manifestations. Thyroxine substitution therapy should be the first line treatment and unnecessary surgery and other treatment should be avoided.
出处
《中华神经外科杂志》
CSCD
北大核心
2010年第4期344-346,共3页
Chinese Journal of Neurosurgery
关键词
甲状腺功能减退
垂体增生
垂体腺瘤
Primary hypothyroidism
Pituitary hyperplasia
Pituitary adenoma
