摘要
目的通过对血清抗炎症介质白介素-10(IL-10)在急性冠脉综合征(ACS)患者中的测定,探讨其在ACS危险分层的临床意义。方法病人分为两组:ACS组[ST段抬高型心肌梗死(STEMI)患者32例,非ST段抬高型心肌梗死/不稳定型心绞痛(NSTEMI/UAP)组患者38例]和对照组[稳定型心绞痛(SAP)患者20例],采用ELISA法分别检测血清IL-10浓度。随访各组于30 d、90 d的后继心血管事件发生率,并对结果进行统计学分析。结果①STEMI和UAP/NSTEMI组患者的血清IL-10水平较SAP组明显降低,差异有显著性(P<0.01);其中STEMI患者血清IL-10水平较UAP/NSTEMI组无显著性差异(P>0.05);②具有高水平IL-10的患者在随后30 d及90 d的心血管事件发生率明显降低。结论血清炎症标志物IL-10可能独立预测近期心血管事件危险性,是评估ACS危险分层的有力指标。
Objective Through the determination of concentration of mediators of anti-inflammation（IL-10） to study the clinic nuance in risk sratification of ACS.Methods 70 ACS（STEMI,NSTEMI/ UAP） patients and 20 SAP patients were selected.The activity of IL-10 were detected by the method of ELISA.We determined the risk for subsequent cardiovascular events during 30 days and 3 months of follow-up,then the results were analyzed.Results ①The concentration of IL-10 was lower in STEMI group and UAP /NSTEMI group than that of SAP group（P〈0.01）.while the difference in the concentration of IL-10 between STEMI group and UAP /NSTEMI group was not significant.②The risk for subsequent cardiovascular events was decreased in patients with higher serum level of IL-10 during 30 days and 3 months of follow-up.Conclusion The serum anti-inflammatory markers（IL-10） were convinced in predicting risk stratification of ACS.And higher concentration of IL-10 serum levels means lower risk for subsequent cardiovascular events.
出处
《滨州医学院学报》
2010年第2期103-105,共3页
Journal of Binzhou Medical University
关键词
白介素-10
急性冠脉综合征
危险分层
易损斑块
interleukin-10
acute coronary syndrome
vulnerable plaque
risk stratification
