摘要
目的比较氟比洛芬酯与曲马多用于颅脑手术术后镇痛的临床效果及不良反应。方法选择择期颅脑手术术后患者60例,随机分为两组,每组30例。A组:于手术结束前30 min静脉给予氟比洛芬酯1.5 mg/kg,B组于手术结束前30 min静脉给予曲马多2 mg/kg,观察术后1 h、3 h、6 h内的疼痛视觉模拟评分(visual analogue scale,VAS)、镇静、恶心、呕吐现象,记录血氧、心率、呼吸频率。结果 A组各时段镇痛满意程度明显高于B组(P<0.05);不良反应中恶心、呕吐普遍低于B组(P<0.05);结论氟比洛芬酯静脉推注用于颅脑手术术后镇痛效果确切,不良反应发生率较曲马多显著降低。
Objective To compare the analgesic efficacy and adverse reactions of flurbiprofen axetil and tramadol in patients undergoing neurosurgery. Methods Sixty patients undergoing neurosurgery were randomly divided into 2 groups （ n = 30）. Group A was administered with 1.5 mg/kg flurbiprofen axetil 30 min before the end of operation; group B was administered with 2 mg/kg tramadol 30 min before the end of operation. The visual analogue scale （VAS） pain score, sedation, nausea and vomiting score were detected at 1 h, 3 h, 6 h after operation, and the blood oxygen, heart rate, respiratory frequency were recorded. Results The analgesic effects of group A at different time was better than that of group B （ P 〈 0.05 ）, and the incidence of adverse reactions of group A, such as nausea and vomiting, was lower than that of group B （P 〈 0.05 ）. Conclusion Flurbiprofen axetil has a good curative effect for postoperative analgesia in neurosurgery with a lower incidence of adverse reactions compared with tramadol.
出处
《中华神经外科疾病研究杂志》
CAS
2010年第2期164-166,共3页
Chinese Journal of Neurosurgical Disease Research
基金
国家自然科学基金资助项目(30873313)
关键词
氟比洛芬酯
曲马多
神经外科术后镇痛
Flurbiprofen axetil
Tramadol
Postoperative analgesia in neurosurgery
