摘要
目的：探讨肾组织纤连蛋白的表达在ＩｇＡ肾病（ＩｇＡＮ）进展中的病理学及临床意义。方法：运用Ｓ－Ｐ法对６０例ＩｇＡＮ的肾活检标本进行纤连蛋白（ＦＮ）、增殖细胞核抗原（ＰＣＮＡ）的免疫组化染色，并与肾小球及肾小管间质损伤程度相对照，进行统计学处理。结果：肾小球系膜区ＦＮ与系膜细胞增生、肾小球损伤程度及肾小管间质损伤程度均呈正相关。基膜ＦＮ的出现与基膜内皮下沉着物、肾小球损伤程度及肾小管间质损伤程度均密切相关。结论：肾小球系膜区ＦＮ可作为肾活检组织病理中肾小球系膜的标志，尤其是基膜ＦＮ的聚集增多。
Purpose To investigate the pathological and clinical significance of fibronectin (FN) expressed in renal tissues with IgA nephropathy (IgA N). Methods Sixty cases of renal biopsy specimens were immunohistochemically stained with antiFN, antiproliferating cell nuclear antigen (PCNA) monoclonal antibodies. All items of the results of immunohistochemical reactions were compared with the glomerular lesion grading and tubulointerstitial lesion grading statistically. Results Positive correlations were found between the degree of FN in glomerular mesangium or basement membranes and glomerular lesion grading or tubulointerstitial lesion grading. Close correlations also existed between the appearance of FN in glomerular basement membranes and that of subendothelial deposits. Conclusion An enhanced expression of FN in mesangium is a marker of mesangium in renal biopsy tissues, and is a reliable indicator to predict progressive disease and worse prognosis, especially the expression of FN in glomerular basement membranes.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第3期244-246,I034,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
纤维蛋白类
IGA肾病
肾组织
glomerulonephritis, IgA
fibronectins
nucleoproteins
preliferating cell nuclear antigen
