摘要
microRNA(miRNA)是一类小RNA分子,在转录后水平对基因的表达进行调控。大量的证据显示绝大多数人类恶性肿瘤具有miRNA异常表型。miRNA与肿瘤中许多细胞过程如分化、增生和凋亡的改变有关。本文回顾了miRNA在肿瘤发生发展中的作用及其作为诊断、预后和治疗工具的可能性。
Recently discovered microRNAs （miRNAs） are a class of small RNA molecules that regulate gene expression at the post-transcriptional level. A large body of evidence implicates aberrant miRNA expression in most human malignancies, miRNAs are involved in many cellular processes that are altered in carcinogenesis, such as differentiation, proliferation and apoptosis. We review the role of miRNAs in the development and progression of cancer and their potential value in the diagnosis, treatment, and prognosis of cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2010年第7期416-420,共5页
Chinese Journal of Clinical Oncology
