重型血友病的临床表现异质性以及抗凝及纤溶因素的影响
被引量：1
摘要
血友病分为轻、中、重三型，其相应的凝血因子活性水平分别为〈1％、1％～5％和5％～30％。重型占60％～70％，若不予替代治疗常频发关节和肌肉出血。但约10％～15％的重型血友病出血表现相对较轻，这一临床异质性的机制未明。除了凝血因子活性水平以外，可能还与基因变异、抗凝、纤溶因素、局部炎症及血管生成因子以及环境因素有关。本综述主要回顾抗凝及纤溶因素的作用。
出处
《国际输血及血液学杂志》
CAS
2010年第2期133-136,共4页
International Journal of Blood Transfusion and Hematology
基金
基金项目：北京市首都医学发展科研基金（20051024）
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