期刊文献+

地西他滨治疗骨髓增生异常综合征一例报告 被引量:10

A case report of decitabine treatment of myelodysplastic syndrome
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摘要 地西他滨是目前治疗骨髓增生异常综合征(MDS)的优先用药,但其在中国尚未展开大规模的临床应用,其应用于中国人的疗效及安全性尚未评估。我院对1例MDS患者进行了地西他滨第1个疗程的治疗,取得满意疗效,提示地西他滨在中国具有良好的应用前景。 Decitabine is now recommended for the treatment of myelodysplastic syndrome (MDS), but its largescale clinical application has not been carried out in China, its efficacy and safety have not been assessed for the Chinese people. We took the first course of decitabine treatment on one patient with MDS, and the efficacy is satisfactory. Revealed that in China, decitabine may has a good application prospects.
出处 《现代医学》 2010年第2期189-190,共2页 Modern Medical Journal
关键词 地西他滨 骨髓增生异常综合征 病例报告 decitabine myelodysplastic syndrome case report
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  • 1Issa JP and KantarJian HP.Introduction emerging role of epigenetic therapy:Focus on Decitabine[J].Semin Hematal,2005,42 (3):1-2. 被引量:1
  • 2Momparler RL.Pharmacology of 5-Aza-2 -deoxycytidine (decitabine)[J].Semin Hematol,2005,42(3):9-16. 被引量:1
  • 3Saba HI,Wijermans PW.Decitabine in myelodysplastic syndroms[J].Semin Hematol,2005,42(3):23 -31. 被引量:1
  • 4Issa J-PJ,Manero GG,Giles FJ,et al.Phase I study of tow-dose prolonged exposure schedule of the hypometylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies[J].Blood,2004,103(5):1636 -46. 被引量:1
  • 5Kantarian HO,Brien S,Giles F,et al.Decitabine low-dose Schedule (100 mg/m2/course) in myelodysplastic syndrome (MDS).Comparison of 3 different dose schedules[J].Blood,2005,106 (11):708. 被引量:1
  • 6Saba HI,lbbert M,Wijermasns PW.Response rats of phase 2 and phase 3.Trials of decitabine (DAC) in patients with myelodys plastic syndromes(MDS)[J].Blood,2005,106(11):706. 被引量:1
  • 7Lbbert M,Minden M.Decitabine in acute myeloid Leukemia[J].Semin Hematol,2005,42 (3):38-42. 被引量:1
  • 8Lbbert M,Rueer B,Schmid M,et al.Contiuned tow-dose Decitabine (DAC) is an active first-line treatment of order AML patients:first results of a multicenter phase Ⅱstudy[J].Blood,2005,106(11):527. 被引量:1
  • 9Cashen A,Shah A,Helget A,et al.A phase I phamacokinetic trial of decitabine administered as a 3-hour infusion to patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS)[J].Blood,2005,106(11):527. 被引量:1
  • 10Scott SA,Dong WF,Ichinohasama R,et al.5-Aza-2'-deoxycytidine (decitabine) can relieve p21 WAF1 repression in human acute leukemia by a mechanism involving release of histone deacetylase 1 (HADC1) without requiring promoter demethylation[J].Leukemia Reseach,2006,30(1):69-76. 被引量:1

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同被引文献75

  • 1肖志坚.循证医学指导下的血液病规范化诊治[J].中国实用内科杂志,2007,27(14):1091-1094. 被引量:18
  • 2陈灏珠,林果为.实用内科学[M].13版.北京:人民卫生出版社,2009:919. 被引量:692
  • 3PINTO A,ZAGONEL V.5-Aza-2′-deoxycytidine(Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes:past,present and future trends[J].Leukemia,1993,7(Suppl.1):51-60. 被引量:1
  • 4CASHEN A F,SCHILLER G J,O'DONNELL M R,et al.Multicenter,phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia[J].J Clin Oncol,2010,28(4):556-561. 被引量:1
  • 5陈书长.骨髓增生异常综合征的诊断和治疗进展[C]//中华医学会第七次全国血液学学术会议论文汇编.北京:中华医学会杂志社,2002. 被引量:1
  • 6DAVID P S,RICHARD M S.Practical recommendations for hypomethylating agent therapy of patients with myelodysplastic syndromes[J].Hematol Oncol Clin N Am,2010,24:389-406. 被引量:1
  • 7KANTARJIAN H,ISSA J P,ROSENFELD C S,et al.Decitabine improves patient outcomes in myelodysplastic syndromes:results of a phase Ⅲ randomized study[J].Cancer,2006,106:1794-1803. 被引量:1
  • 8WIJERMANS P,LUBBERT M,VERHOEF G,et al.Low-dose 5-aza-2′-deoxycytidine,a DNA hypomethylating agent,for the treatment of high-risk myelodysplastic syndrome:a multicenter phase Ⅱ study in elderly patients[J].J Clin Oncol,2000,18:956-962. 被引量:1
  • 9GAUTAM B,SAMIH E A,FARHAD R,et al.Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine[J].Leukemia & Lymphoma,2008,49:690-695. 被引量:1
  • 10Zagonel V. 5 -aza-2-decitabine induces trilineage response in unfavourable myelodysplastic syndromes [ J ]. Leukemia, 1993,7 (11) :30-35. 被引量:1

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