摘要
目的:探讨鼻腔鼻窦型血管外皮细胞瘤(SNTHPC)的病理形态学特点、组织发生、诊断和鉴别诊断、治疗及预后。方法:结合文献复习,对1例SNTHPC患者的临床病理资料进行总结。手术摘除标本采用常规石蜡切片、HE染色,并根据HE染色结果对石蜡切片采用EnVision免疫组化二步法染色、网状纤维染色和Giemsa染色,以进一步和多种肿瘤进行鉴别诊断。结果:免疫组化染色见瘤细胞表达Actin(+),Vimentin(+),CD34弱(+),GFAP弱(+),Bcl-2弱(+),S100个别细胞(+),Ki-67约1%(+),CD99(-),CD117(-);网状纤维染色示网状纤维围绕于大多数瘤细胞周围。结论:免疫组化提示SNTHPC是真正的向血管周细胞性平滑肌方向分化的肿瘤。该肿瘤少见,大多数具有惰性的生物学行为,尚需结合免疫组化与多种肿瘤进行鉴别。
Objective： To explore the pathomorphological features, histogenesis, diagnosis, differential diagnosis, therapy and prognosis of the sinonasal-type haemangiopericytoma （SNTHPC）. Methods： The tissues of SNTHPC were embeded in paraffin and sliced into sections, and then the sections were stained with HE. Immunohistoehemical method（ EnVision method）, reticular fiber staining and Giemsa staining were then used to further differentiate it from other tumors. Results： Immunohistochemical staining revealed that the tumor cells expressed Actin （ ＋ ）, Vimentin （ ＋ ）, CD34 weak（ ＋ ） ,GFAP weak （ ＋ ）, Bel-2 weak （ ＋ ）, S100 apart cells （ ＋ ） ,Ki-67 about 1% （ ＋ ）, CD99 （ - ）, and CD117 （ - ）. Reticular fiber staining showed that the majority of tumor cells were surrounded by the reticular fibers. Conclusion： Immunohistochemistry suggests that the sinonasal-type haemangiopericytoma is a truly perivascular cell tumor with myoid differentiation. The tumor is rare with an overall excellent survival but it still should be differentially diagnosed from other tumors.
出处
《现代医学》
2010年第2期102-106,共5页
Modern Medical Journal
