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骨肉瘤细胞转录因子NF-κB表达与预后的研究 被引量:3

High expression of NFkappa B transcription factor and its prognostic significance in osteosarcoma
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摘要 目的:研究NF-κB高表达与骨肉瘤预后的关系。方法:应用免疫组化方法检测80例骨肉瘤NF-κBp65的表达。结果:80例骨肉瘤中48例NF-κBp65阳性(60%)。NF-κB的高表达与骨肉瘤肿瘤性骨样组织分型、WHO分型(1993)以及骨肉瘤预后有关。 Purpose To examine the expression of nuclear factor kappa B(NFκB) and its relationship to the prognosis in osteosarcoma. Methods The expression of NFκB were analyzed immunohistochemically in 80 cases of osteosarcoma. Results Fortyeight of 80 osteosarcomas were found positive staining of NFκB p65 subunit (60%). The high expression of NFκB was found significant correlation with neoplastic osteoid classification, WHO classification in 1993 and the prognosis of osteosarcomas. Conclusion The results suggest that NFκB may serve as a new biological indicator to predict the prognosis of patients with osteosarcoma.
出处 《临床与实验病理学杂志》 CAS CSCD 1998年第3期250-252,I034,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 NF-ΚB 骨肉瘤 细胞转录因子 osteosarcoma NFκB prognosis
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参考文献11

  • 1Dorfman HD, Czerniak B, Bone caucers. Cancer, 1995,75(1):203-210. 被引量:1
  • 2Siebenlist U, Franzoso G, Brozon K. Structure, regulation and functions of NF-kappa B Ann Rev Cell Biol, 1994,10:455. 被引量:1
  • 3Price CH. Osteogenic sarcoma: An analysis, of survival and its relationship to histological grading and structure. J Bone Joint, Surg,1961,43(B):300-306. 被引量:1
  • 4Dahlin DC, Coventry MB, Osteogenic sarcoma: A study of 600 cases, J Bone Joint Surg, 1967,49(A):101-105. 被引量:1
  • 5王东,高奉浔.骨肉瘤肿瘤性骨样组织分型的立体计量学与预后的研究[J].中华病理学杂志,1990,19(4):268-270. 被引量:4
  • 6Schajowicz F, Sissons HA, Sobin H The World Health Organization's histologic classification of bone tumor. A commentary on the second edition Cancer, 1995,75:l208-1218. 被引量:1
  • 7Boars V, Dejardin E, Goujon LF. et al, The NF-kappa B transcription factor and cancer, high expression of NF-kappa B-and I kappa B-related proteins in tumor cell lines. Biochem Parmacol, 1994,47(1):145-149. 被引量:1
  • 8Higgins KA, Derez JR, Coleman TA, et al. Antisense inhibition of the p65 suhunit of NF-B blocks tumorigenicity and causes tumor regression Proc Natl Acad Sci USA, 1993,90:9901-9905. 被引量:1
  • 9Yang J, Xu Y, Zhu C, et al. Regulation of adhesion molecule expression in Kaposi's sarcoma cells. J Immunol, 1994, 152(1) :361-378. 被引量:1
  • 10王东,陈俐,高奉浔.骨肉瘤p53蛋白过度表达与预后的关系[J].临床与实验病理学杂志,1997,13(1):45-47. 被引量:5

二级参考文献3

  • 1吴祖尧,中华骨科杂志,1988年,3卷,231页 被引量:1
  • 2刘昌茂,实用病理学杂志,1987年,1期,1页 被引量:1
  • 3刘子君,中华肿瘤杂志,1983年,5卷,340页 被引量:1

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  • 1Wang W, Abbruzzese JL, Evans DB, et al. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res , 1999,5(1) : 119- 127. 被引量:1
  • 2Huang S, Pettaway CA, Uehara H, et al. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene,2001,20(31), 4188-4197. 被引量:1
  • 3Steeg PS , Bevilacqua G ,Kopper L, et al. Evidence for a novel gene associated with low tumor metastatic potential[J].J Natl Cancer Inst,1988,80:200-204. 被引量:1
  • 4Venturelli D, Martinez R, Melotti P, et al. Over expression of inhibits granulocyte differentiation and induces apoptosis in 32Dcl3 myeloid cell[J]. Proc Natl Acad Sci USA,1995,92:7435-7439. 被引量:1
  • 5Caligo MA, Grammatico P, Cipollini G, et al. A low nm23H1 gene expression identifying high malignancy human melanomas[J]. Melanoma Res, 1994,4:179-184. 被引量:1
  • 6Martinez R, Venturelli D, Perrorri D, et al. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene , a related member of the nm23 gene family[J].Cancer Res, 1997, 57 (6):1180-1187. 被引量:1
  • 7Florenes VA, Aamdals, Myklebost O,et al . Levels of nm23 messenger RNA in malignant melanomas : inverses correlation to disease progression[J]. Cancer Res,1992,52:6088. 被引量:1
  • 8Sarbia M, Porschen R, Borchard F, et al. Incidence and prognostic significance of the esophagus[J]. Int J Cancer,1995,61:333-336. 被引量:1
  • 9Masalki Tomita ,Takanori Ayabe ,Yasunori Matsuzaki ,et al. Expression of nm23H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival[J]. BMC Cancer,2001,1(1):3. 被引量:1
  • 10Robert P Takes, Robert J, Baatenburg de Jong, Karien Wijffels. Expression of genetic markers in lymph node metastases compared with their primary tumors in head and neck cancer[J]. Pathol, 2001,194(3):298-302. 被引量:1

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