摘要
目的:研究NF-κB高表达与骨肉瘤预后的关系。方法:应用免疫组化方法检测80例骨肉瘤NF-κBp65的表达。结果:80例骨肉瘤中48例NF-κBp65阳性(60%)。NF-κB的高表达与骨肉瘤肿瘤性骨样组织分型、WHO分型(1993)以及骨肉瘤预后有关。
Purpose To examine the expression of nuclear factor kappa B(NFκB) and its relationship to the prognosis in osteosarcoma. Methods The expression of NFκB were analyzed immunohistochemically in 80 cases of osteosarcoma. Results Fortyeight of 80 osteosarcomas were found positive staining of NFκB p65 subunit (60%). The high expression of NFκB was found significant correlation with neoplastic osteoid classification, WHO classification in 1993 and the prognosis of osteosarcomas. Conclusion The results suggest that NFκB may serve as a new biological indicator to predict the prognosis of patients with osteosarcoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第3期250-252,I034,共4页
Chinese Journal of Clinical and Experimental Pathology