摘要
目的:探讨多发性硬化(MS)早期常规MR扫描表现正常的胼胝体的磁共振弥散张量成像(DTI)的改变。方法:20例病程相对较短(平均2.3年)的MS患者和20个年龄性别相匹配的健康志愿者为对照进行MR扫描,获取高分辨常规MRI(T1WI、T2WI、FLAIR)图像及DTI图像,获得表现正常胼胝体(NACC)和额、枕部表现正常白质(NAWM)的部分各向异性指数(FA)值和平均扩散系数(MD)值。结果:早期MS患者的NACC与正常对照比较,其FA值显著下降(P<0.001)、MD值显著增加(P<0.001);早期MS患者额、枕部的NAWM和正常对照比较,其FA值(P=0.216)、MD值(P=0.673)差异均无统计学意义。NACC的平均MD值和反映脑实质中央性萎缩的Evans指数间存在相关性(r=0.648,P=0.043)。结论:定量磁共振弥散张量值(FA值和MD值)的变化表明MS疾病早期损害优先出现在胼胝体,胼胝体的结构特点可能是其在MS早期易受损害的重要原因。定量DTI可用于监控和评估早期MS患者NACC的改变和预后。
Objective： To investigate the quantitative diffusion tensor imaging（DTI） changes of normal-appearing corpus callosum （NACC） and other normal-appearing white matter （NAWM） in patient with early multiple sclerosis （MS）. Materials and Methods： Conventional magnetic resonance imaging （cMRI） and DTI were performed in 20 healthy volunteers and 20 patients with same gender/age who had relatively short disease duration （mean 2.3 years）. Quantitate DTI values-fractional anisotropy （FA）/mean diffusivity （MD） of NACC and NAWM in frontal and occipital regions were measured and analyzed. Results： In comparison with controls, the patient with early MS had significantly lower FA （P〈0.001） and higher MD （P〈0.001） for NACC regions, but FA values（P=0.216） and MD values（P=0.673） in frontal and occipital regions did not show any significant difference between the two groups. The change of FA/MD in the entire NACC regions was correlated with the values of Evans （r= 0.648, P=0.043） in patients. Conclusion： The quantitative DTI value（FA and MD） changes indicated that in early phase of MS there is a preferential occult injury of CC, which is likely due to the corpus callosum construction features. Quantitative DTI could help better evaluation of therapeutic options and prognosis of patients with multiple selerosis.
出处
《中国临床医学影像杂志》
CAS
北大核心
2010年第4期233-235,260,共4页
Journal of China Clinic Medical Imaging
关键词
多发性硬化
胼胝体
磁共振成像
Multiple sclerosis
Corpus callosum
Magnetic resonance imaging
