摘要
RUNX1又称为AML1,是RUNX转录因子蛋白家族中的成员之一,是白血病染色体易位最常见的靶位点。RUNX1是十分重要的转录因子,可双向(促进或抑制)调节造血相关基因的表达。RUNX1蛋白可接受多种翻译后修饰,其活性可受这些翻译后修饰的影响,从而调节造血细胞的分化、凋亡及自我更新。本文重点综述RUNX1的靶基因、转录机制及翻译后修饰等表观遗传机制在白血病发生中的作用。
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may recieve a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoiestic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
出处
《中国实验血液学杂志》
CAS
CSCD
2010年第2期525-530,共6页
Journal of Experimental Hematology
基金
国家高技术研究发展计划(863计划)现代医学技术专题项目
编号2006AA02ZAZ2
关键词
RUNX1
白血病
转录因子
翻译后修饰
RUNX1
leukemia
transcriptional factor
post-translational modification
