摘要
背景:睫状神经营养因子广泛分布于神经系统,具有广谱营养作用。目的:综述国内外关于睫状神经营养因子在神经损伤及修复中的地位与应用前景。方法:计算机检索中国期刊全文数据(网址http://dlib.cnki.net/kns50/index.aspx)及PubMed数据库(网址http://www.ncbi.nlm.nih.gov/pubmed/)1990-01/2009-06期间相关文章,检索词为"睫状神经营养因子,神经损伤,Ciliary neurotrophic factor,Nerve injure"。纳入与神经损伤与睫状神经营养因子研究现状与发展密切相关的研究,包括神经元损伤后的变化;睫状神经营养因子对神经元的修复机制及保护作用,对修复过程的调控,对神经元轴浆运输功能的恢复,对损伤神经的再生作用。排除重复性研究或Meta分析。结果与结论:睫状神经营养因子广泛分布于神经系统,具有广谱营养作用。神经元内源性睫状神经营养因子主要来源于周围神经许旺细胞、中枢神经胶质细胞以及神经元的自分泌。在神经损伤的修复过程中,睫状神经营养因子通过不同的方式对损伤神经元进行保护和修复。睫状神经营养因子可以通过对几种相关酶的调节而促进神经损伤的恢复,能提高细胞内JAK-STAT途径促进相关蛋白和重要分子的产生,可以促进轴浆运输,使修复加快,睫状神经营养因子还可以通过加强许旺细胞的增殖和变化促进神经的修复。睫状神经营养因子在受损神经元的修复中起着很重要的作用。通过研究探索睫状神经营养因子对神经损伤治疗的作用,有利于开发应用睫状神经营养因子来治疗神经损伤。
BACKGROUND：Ciliary neurotrophic factor（CNTF） is widely distributed in neuronal system,which has nutritional function.OBJECTIVE：To summarize the position and application prospect of CNTF on neural injury and reparation in China and abroad.METHODS：Computer-based online search of Chinese Full Text Databases（website：http：//dlib.cnki.net/kns50/index.aspx） and PubMed databases（website：http：//www.ncbi.nlm.nih.gov/pubmed/） was performed with keyd words of ＂Ciliary neurotrophic factor,Nerve injure＂ from January 1990 to June 2009.Research concerning research status and development of CNTF was selected,including changes of CNTF following nerve injury;the repair mechanism and protection of CNTF on neurons;regulation on reparative process;the recovery of axoplasmic transport function of axoplasm,as well as the regeneration on injured nerves.The repeated research or Meta analysis was excluded.RESULTS AND CONCLUSION：CNTF had trophic action and was widely distributed in nervous system.The source of endogenous CNTF was autocrine of Schwann cells,glial cells and neurons.In the repair process of nerve injury,CNTF protected and repaired the injured nerves via various ways,such as regulated related enzyme expression,boost JAK-STAT to promote production of GAP-associated protein GAP and molecular,advance axoplasmic transport and restore,and promote neural restore by enhancing Schwann corpuscular vegetation variation.CNTF plays an important role in the recovery of injured nerves.Studies regarding the effects of CNTF on neural injuries are providing a basis for its clinical application.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第15期2810-2813,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
