摘要
本文研究了静脉注射八肽胆囊收缩素(CCK-8)对胃肌电快波簇的作用是否与中枢阿片肽有关.结果表明,静脉注射CCK-8,可抑制胃肌电快波簇的频率和振幅;侧脑室注射纳洛酮,可使胃肌电快波簇的频率和振幅均明显增大.侧脑室注射纳洛酮可阻断静脉注射CCK-8对胃肌电快波簇频率和振幅的抑制作用.提示,静脉注射CCK-8对胃肌电快波簇的抑制作用与中枢阿片肽有关.
Experiments were carried out on rats anaesthetized with urethane in order to study the relationship between the effect of intravenous injection of cholecystokinin-8 (CCK-8) on stomach myoelectric spike burst (SMSB) and central opioid peptides. After the left upper abdominal wall was cut open and the stomach exposed, bipolar electrodes made up of chrome-nickel string were inserted into the stomach muscle layer to record SMSB passing through bitract physiological recorder. Intravenous injection of CCK-8 decreased the frequency and amplitude of SMSB. Intracerebroventricular injection (I.C.V.) of naloxone potentiated the frequency and amplitude of SMSB. These suppressive effects of CCK-8 were blocked by naloxone (I.C.V.). The results suggest that the inhibitory effects of CCK-8 on SMSB may be mediated by opioid peptiedes in brain.
出处
《青岛医学院学报》
1990年第4期309-312,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
CCK-8
胃肌
电快波簇
钠洛酮
Cholecystokinin
Opioid peptide
Naloxone
Stomach myoelectric spike burst
Rats
