摘要
胎盘滋养细胞正常侵入,子宫螺旋动脉成功重铸是正常妊娠的关键。Fas/Fasl系统在正常妊娠滋养细胞侵入,子宫螺旋动脉内皮细胞、平滑肌细胞凋亡方面发挥重要作用,有助于妊娠的维持。Fas/Fasl系统的表达异常引起子宫螺旋动脉重铸障碍能导致子痫前期的发生。对其深入研究,有助于揭示子痫前期的发病机制,有望为子痫前期的治疗提供新的靶点。
Normal invading of the placental cytotrophoblasts and successful remodeling of the uterine spiral arteries are the key points in normal pregnancy.Fas/Fasl system playing an important role in the invasion of cytotrophoblasts and apoptosis of endothelial and smooth muscle cells of the uterine spira arteries.Abnormal expression of Fas/Fasl system may participate in the defective remodeling of the spiral arteries is associated with preeclampsia.Deep investigation of Fas/Fasl system make for revealing pathogenesy and providing novel therapeutic approaches for preeclampsia.
出处
《中国优生与遗传杂志》
2010年第4期142-143,共2页
Chinese Journal of Birth Health & Heredity
