摘要
凋亡和自噬是参与维持机体正常的生理平衡和内环境稳定重要机制,与正常生长发育以及肿瘤等多种疾病发展过程都有着密切的联系。对于肿瘤的治疗,传统的方法是诱导肿瘤细胞凋亡,然而,肿瘤细胞中凋亡抗性的出现成为肿瘤治疗的主要障碍。近来,通过诱导其它细胞死亡方式致肿瘤细胞死亡已经成为有潜力的新的抗肿瘤机制。自噬作为另外一种细胞程序性死亡方式与凋亡一样有着复杂的分子机制和调控机制,它们之间存在密切的联系,并且存在许多相同的调节蛋白。本文就凋亡和自噬在形态特征、分子机制、检测方法以及在肿瘤治疗过程两者之间的关系做一综述。
Both apoptosis and autophagy play vital roles in the maintenance of normal physiological balance and the stability within the environment. They are intimately connected with growth development and the a variety of disease processes such as tumor. For the tumor treatment,traditional cancer therapy evokes cell death by inducing apoptosis, however, the apoptotic resistance inherent in cancer cells has been a significant barrier to effective chemotherapy. More recently, other mechanisms of cell death have emerged as potential novel mechanisms for cancer therapies to induce cell death. As another programmed cell death autophagy also have complex molecular and regulatory mechanism, the relationship between them is closely and there are the same regulatory factors. This review focuses on the distinctive of morphologic characteristics, molecular mechanism, measurement and the relationships in tumor therapy.
出处
《现代生物医学进展》
CAS
2010年第4期766-769,共4页
Progress in Modern Biomedicine
关键词
凋亡
自噬
肿瘤治疗
Apoptosis
Autophagy
Tumor therapy
