摘要
目的通过对近5年细辛脑注射液致不良反应报告的回顾性研究,探讨该药品产生不良反应的类型、规律及趋势。方法检索CNKI、维普期刊数据库与Google、百度等搜索引擎,统计细辛脑注射液致不良反应病例报告。结果共发现细辛脑注射液致不良反应报告128例,其中全身过敏样反应66例(过敏性休克34例),消化系统损害27例,皮肤及其附件损害26例,其他不良反应9例,儿童患者发生不良反应的比例占87.5%。制剂处方中的吐温-80是导致其过敏性不良反应的主要原因。结论细辛脑注射液致不良反应引起高度重视,须尽快开展该药品的安全性研究工作。
Objective This article reviews adverse reactions caused by asarone injection in the past 5 years and analyzes the type,characteristics and tendency.Methods One hundred and twenty-eight cases of adverse reaction reports Cansed by asarone injection were collected by searching for CNKI and VIP journals database,and as well as google and baidu search engines.Results It was found that the chief adverse reaction was systemic anaphylaxis in total case,come to 66 cases including 34 cases of serious anaphylactic shock.Skin and its accessories damage accounted for 26 cases,digestive system damage took place 27 cases and other adverse reactions contributed 9 cases.Most adverse effect cases are related to infant patient,approaching to 87.5% in all cases.We investigated anaphylaxis factor in the formula of asarone injection and detected that tween-80 is principal factor causing the adverse reactions.Conclusion We must attach great importance to the adverse reactions and improve medication safety of the high risk asarone injection as soon as possible.
出处
《中国药物警戒》
2010年第4期243-246,共4页
Chinese Journal of Pharmacovigilance
