摘要
目的:建立射精管部分梗阻致大鼠血精模型,探讨血精症发病机制。方法:成年雄性SD大鼠50只,分为A组(30只)和B组(20只)。将A组大鼠行右侧射精管部分结扎,B组仅行开关腹(假手术)。于手术后1周行电刺激诱导射精,从A组中选出产生肉眼血精者设为A1组(实验组),从B组中选出射精功能完好者设为B1组(对照组),比较两组间精液常规及精囊内压力。结果:A1组精液量[(0.46±0.12ml]较B1组[(0.91±0.12)ml]减少,差异有显著性(P<0.01);两组精液中白细胞数[(0.83±0.75)/HPvs(0.89±0.78)/HP]及精子密度[(29.85±1.68)×106/mlvs(30.58±1.64)×106/ml]均无统计学差异(P>0.05)。A1组精子活动力[(36.35±3.52)%]较B1组[(61.02±5.35)%]明显减小,有显著性差异(P<0.01)。A1组精囊内压较B1组[(6.73±1.50)cmH2Ovs(1.39±0.56)cmH2O]明显增大,有显著性差异(P<0.01)。结论:射精管部分梗阻可引发血精,且伴随有精液指标的变化,其发生与精囊内压力增高密切相关。
Objective：To investigate the pathogenesis of hematospermia syndrome using the rat model of hemospermia induced by partial ejaculatory duct obstruction.Methods：Fifty male rats were divided into Groups A（n = 20）and B（n = 30）,the former subjected to incomplete ligation of the right ejaculatory duct,while the latter open-close sham operation.Electro-stimulation was performed for ejaculation induction one week after the operation.Those that developed hematospermia in Group A were chosen as Group A1,while those with normal ejaculation in Group B included in Group B1.The semen indexes and seminal vesicle pressure were compared between Groups A1 and B1.Results：Compared with Group B1,Group A1 showed significantly decreased semen volume（P 0.01）,lower sperm motility（P 0.01）and higher seminal vesicle pressure（P 0.01）,but no statistically significant differences were observed in the WBC count and sperm density in the semen between the two groups（P 0.05）.Conclusion：Hemospermia syndrome can be induced by partial ejaculatory duct obstruction,with changes of semen indexes,and it is closely correlated with high seminal vesicle pressure.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第3期240-243,共4页
National Journal of Andrology
关键词
血精
射精管部分梗阻
精囊内压力
机制
动物模型
rat model
hematospermia
pathogenesis
partial ejaculatory duct obstruction
seminal vesicle pressure
