摘要
目的:检测URG4在肝癌组织中的表达及意义。探讨URG4与HBx在肝癌组织表达之间的关系。方法:免疫组化方法检测URG4和HBx在正常组织、肝癌组织及癌旁组织中的表达分布,并分析其表达的意义及表达之间的相关性。结果:URG4在肝癌组织及肝癌细胞系中的阳性表达率分别为48%和54%,而在正常组织中仅22.2%弱表达,其与HBx表达的相关系数分别为0.38和0.45(P<0.05)。结论:URG4在肝癌组织及癌旁组织中的表达高于正常组织,且与HBx密切相关。
AIM：To investigate the expression of UR-G4 in HCC（Hepatocellular carcinoma） and its correlation with HBx.METHODS：Immunohistochemistry was perfomed to examine the expression of URG4 and HBx in HCC tissues,adjacent nontumor tissues and normal liver tissues.RESULTS：The expression rate of URG4 in HCC tissues and adjacent nontumor tissues were 48% and 54% respectively,while there was only 22.2% weak URG4 expression in normal tissues.Correlation coefficient between expression of HBx and URG4 was 0.38 in HCC tissues（P0.05） and 0.45 in adjacent nontumor tissues（P0.05）.CONCLUSION：Expression of URG4 in HCC tissues,adjacent nontumor tissues,and HCC cell lines was much higher than that of normal tissues and cells.Expression of URG4 in HCC is closely related with HBx.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2010年第3期264-266,共3页
Chinese Journal of Cellular and Molecular Immunology
基金
国家高技术研究发展计划(863)资助项目(2006AA02z468)
关键词
URG4
肝细胞肝癌
乙肝病毒X蛋白
URG4
hepatocellular carcinoma
hepatitis B virus X protein
