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胃肠道间质瘤的临床研究进展 被引量:4

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摘要 胃肠道间质瘤是消化道最常见的间叶源性肿瘤,由梭形、上皮样或多形性细胞构成,免疫组织化学以表达CD117为特征,由突变的c-Kit或血小板源生长因子受体(PDGFRA)基因所驱动,在生物学行为上目前多认为有潜在恶性倾向。现主要以手术治疗,而分子靶向药物治疗也能够取得较好的疗效。
作者 尧登华 黄华
出处 《国际消化病杂志》 CAS 2010年第2期90-92,共3页 International Journal of Digestive Diseases
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参考文献25

  • 1Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol, 2003, 54:3-24. 被引量:1
  • 2De Matteo RP,Lewis JJ,Leung D,et al. Two hundred gastrointestinal stromal tumors:recurrence patterns and prognostic factors for survival. Ann Surg, 2000, 231:51-58. 被引量:1
  • 3中国胃肠道间质瘤病理共识意见[J].中华病理学杂志,2007,36(10):704-707. 被引量:109
  • 4Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long term follow-up. Am J Surg Pathol, 2005, 29: 52-68. 被引量:1
  • 5De Giorgi U, Verweij J. Imatinib and gastrointestinal stromal tumors:Where do we go from here? Mol Cancer Ther, 2005, 4: 495-501. 被引量:1
  • 6Miettinen M, Makhlouf H, Sobin LH, et al. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistoehemical, andmolecular genetic study of 906 cases before imatinib with long term follow up. Am J Surg Pathol, 2006, 30: 477-489. 被引量:1
  • 7Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol, 2003, 21: 4249-4342. 被引量:1
  • 8Lasota J, Corless CL, Heinrich MC, et al. Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases. Mod Pathol, 2008, 21 : 476-484. 被引量:1
  • 9Corless CL, SchroederA, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol, 2005, 23: 5357-5364. 被引量:1
  • 10Dirnhofer S, Zimpfer A,Went P. The diagnostic and predictive role of kit(CD117). Ther Umsch, 2006, 63:273-278. 被引量:1

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  • 1王振华,梁小波.胃肠道间质瘤流行病学研究进展[J].国际流行病学传染病学杂志,2013,40(3). 被引量:10
  • 2Wynn ML, Ventura AC, Sepulchre JA, et al. Kinase inhibitors canproduce off-target effects and activate linked pathways by retroactivity. BMC Syst Biol, 2011,5(1) :156. 被引量:1
  • 3Han W, Pan H, Chen Y, et al. EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One, 2011,6(6) :e18691. 被引量:1
  • 4Yoshida T, Zhang G, Haura EB. Targeting epidermal growth factor receptor: central signaling kinase in lung cancer. Biochem Pharmacol. 2010.80(5):613-623. 被引量:1
  • 5Scahriti M, Rojo F, Ocana A, et al. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst, 2007, 99 (8) :628-638. 被引量:1
  • 6Zhang J, Roberts TM, Shivdasani RA. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology, 2011, 141 ( 1 ) :50-61. 被引量:1
  • 7Tzvetkov MV, Behrens G, O'Brien VP, et al. Pharmacogenetic analyses of cisplatin-induced nephrotoxicity indicate a renoprotective effect of ERCC1 polymorphisms. Pharmacogenomics, 2011, 12(10) : 1417-1427. 被引量:1
  • 8Nitiss JL. Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer, 2009, 9(5) :338-350. 被引量:1
  • 9Boukovinas I, Papadaki C, Mendez P, et al. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. PLoS One, 2008, 3 ( 11 ) : e3695. 被引量:1
  • 10Schwab M, Zanger UM, Marx C, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol, 2008, 26(13) :2131-2138. 被引量:1

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