摘要
目的探讨芭蕉根不同极性溶剂提取物的抗炎、镇痛活性。方法采用二甲苯致小鼠耳肿胀实验、角叉菜胶致小鼠足肿胀和小鼠棉球肉芽肿等实验进行抗炎实验,采用醋酸扭体法进行镇痛实验,对芭蕉根的石油醚提取物、正丁醇提取物,80%乙醇提取物和水提取物进行抗炎和镇痛实验研究。结果芭蕉根石油醚和正丁醇提取物可以明显的减轻二甲苯所致的小鼠耳廓肿胀和棉球肉芽肿的重量,对角叉菜胶所致的小鼠足肿胀也有明显的抑制作用;芭蕉根乙醇提取物和水提取物对醋酸所致小鼠扭体反应有较好的抑制作用。结论在相同剂量下,芭蕉根石油醚提取物和正丁醇提取物显示出较好的抗炎活性,而80%乙醇和水提取物相对具有较好的镇痛活性。
Objective To evaluate the anti - inflammatory and analgesic effects of different extracts from Musa basjoo. Methods Samples were extracted from Musa basjoo with ethyl acetate, n - butyl alcohol, 80% alcohol or water. Anti - inflammatory effect of Musa basjoo were observed by mouse abdominal cavity capillary permeability increase test induced by acetic acid, mouse auricle swelling test induced by xylene, mouse pedal swelling test induced by carrageenin and cotton granuloma test in mice. algesic action of Musa basjoo was observed by mouse aceticacid - induced twisting test. Results In the same dose, both of the sample of ethyl acetate and n - butyl alcohol could reduce pedal swelling, aurical swelling and cotton granuloma of mice. Both of the sample of 80% alcohol and water sample could inhibit twisting response of mice obviously. Conclusion Both of the sample of ethyl acetate and n - butyl alcohol have anti - inflammatory action, while both of the sample of 80% alcohol and water have analgesic effect.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第4期780-781,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(No.30860387)
贵州省科学技术基金(No.[J]20072138)
关键词
芭蕉根提取物
镇痛作用
抗炎作用
Extracts of Musa basjoo
Analgesic action
Anti - inflammation
