摘要
目的探讨慢性心力衰竭(CHF)患者血清白细胞介素-6(IL-6)水平的变化及血管紧张素转换酶抑制剂(ACEI)对其影响。方法采用双抗体夹心(ELISA法)检测38例CHF患者及23例健康自愿者血清IL-6水平,将CHF患者随机分为常规治疗组(17例)和常规治疗+ACEI治疗组(21例)共观察4周。结果(1)CHF患者血清IL-6水平显著高于健康对照组(P<0.01),且与左室射血分数(LVEF)呈负相关(r=-0.52,P<0.05);(2)经4周治疗后ACEI组患者IL-6水平明显降低(P<0.05),且伴有心率明显下降(P<0.05)和LVEF明显增高(P<0.05)。结论CHF患者IL-6水平明显增高,并与左室收缩功能负相关,ACEI可降低血清IL-6水平,有助于CHF患者心功能的改善。
Objective To study the effects of angiotension converting enzyme inhibitors（ACEI） on serum interleukin-6（IL-6） in patients with chronic heart failure（CHF）.Methods Serum IL-6 in 38 patients with chronic congestive heart failure and 23 healthy controls were measured by enzyme-1inked immunosorbent assay.The patients with CHF were randomized to receive routine therapy（routine group,n=17） or ACEI in addition to routine therapy（ACEI group,n=21） for 4 weeks.Evaluations were made before and after treatment.Results（1） Levels of IL-6 in the CHF patients were significantly higher than those in the controls,and the serum level of IL-6 was negatively related to left ventricular ejection fraction（LVEF）（r =-0.52,P 0.01）.（2）After treatment,the level of IL-6 decreased in ACEI group（P 0.05）,with lower heart rates and increased LVEF（P 0.05）.Conclusion Elevated IL-6 levels are present in patients with CHF,ACEI can decrease the IL-6 levels in patients with CHF,which may play an important role in improving of the function of the left ventricle.
出处
《济宁医学院学报》
2010年第2期109-111,共3页
Journal of Jining Medical University
