摘要
目的观察灯盏花素注射液治疗冠心病不稳定型心绞痛的疗效及对凝血指标、高敏C反应蛋白(highsensitive C-reactive protein,hs-CRP)、血脂、血糖的影响。方法选择40例冠心病不稳定型心绞痛患者,随机分为治疗组和对照组各20例,治疗组给予灯盏花素注射液加西药常规治疗,对照组仅予西药常规治疗,观察治疗前后心绞痛、心电图、中医证候疗效及凝血酶原时间(prothrombin ti me,PT)、活化部分凝血活酶时间(activated partial thromboplastin ti me,APTT)、血浆纤维蛋白原(plasma fibrinogen,FG)、hs-CRP及血脂、血糖等指标变化。结果治疗组在缓解心绞痛症状和改善心电图疗效方面与对照组比较,差异无统计学意义(P>0.05),在改善中医证候疗效方面显著优于对照组(P<0.05)。治疗组在升高PT、APTT,降低FG和hs-CRP方面显著优于对照组(P<0.05,或P<0.01),治疗组总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、空腹血糖(fasting plasma glucose,FPG)及餐后2小时血糖(two-hours postprandial plasma glucose,2hPG)显著降低(P<0.05,或P<0.01),高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)无显著变化(P>0.05);对照组LDL-C、FPG和2hPG(P<0.05)显著降低,TC、TG和HDL-C无显著变化(P>0.05)。治疗组治疗后LDL-C显著低于对照组(P<0.05)。结论灯盏花素注射液可改善冠心病不稳定型心绞痛患者的中医证候,改善凝血指标,降低hsCRP,并且具有一定的调脂、降糖作用。
Objective To observe therapeutic effects of Breviscapine Injection in the treatment of coronary heart disease with unstable angina pectoris and its effect on blood coagulation indicators, high-sensitivity C-reactive protein （hsCRP）, blood lipids and blood glucose. Methods Forty patients with unstable angina pectoris were randomly divided into the treatment group （20 cases） and the control group （20 cases）. The treatment group was administered with Breviscapine Injection combined with western conventional medicine, and the control group with western conventional medicine only. Before and after treatment, therapeutic effects of angina pectoris, electrocardiogram （ECG）, traditional Chinese medicine （TCM） syndrome and changes of prothrombin time （PT）, activated partial thromboplastin time （APTT）, plasma fibrinogen （FG）, high-sensitivity C-reactive protein （hs-CRP）, blood lipids and blood glucose were observed. Results There was no significant difference in alleviating the symptoms of angina pectoris and improving therapeutic effect of ECG between the control group and the treatment group （P〉 0. 05）. Therapeutic effect of TCM syndrome in the treatment group was significantly better than that in the control group （P〈0.05）. Levels of PT and APTT were significantly increased and levels of FG and hsCRP were significantly decreased in the treatment group compared with those in the control group （P〈0.05, or P〈0.01）. In thetreatment group, levels of total cholesterol （TC）, low density lipoprotein-cholesterol （LDL-C）, triglyceride （TG） and two-hours postprandial plasma glucose （2hPG） were significantly decreased （P〈0.05, or P〈0. 01）, while the level of high density lipoprotein-eholesterol （HDL-C） showed nonsignificant change （P〉0.05）. In the control group, levels of LDL-C,fasting plasma glucose and 2hPG were significantly decreased （P〈0.05）, and levels of TC, TG and HDL-C showed nonsignificant change （P〉0.05）. After treatment
出处
《安徽中医学院学报》
CAS
2010年第2期14-16,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
冠心病不稳定型心绞痛
灯盏花素注射液
凝血指标
血脂
血糖
Coronary heart disease
Unstable angina pectoris
Breviscapine Injection
Blood coagulation indicators
Blood lipid
Blood glucose
