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GLP-1对心脏的作用和治疗潜力 被引量:2

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摘要 GLP-1是一种主要由远端回肠、直肠和结肠的L细胞分泌的多肽激素,肠腔内营养物质如葡萄糖、脂肪等能直接刺激GLP~1的释放。据报道,GLP一1的基础水平约在(0.4~1.4)×10~12mol/L,在进食几分钟后,人体内的GLP一1浓度开始升高,在餐后30~60分达到峰值,高峰浓度约(10~12)×10~12mol/L。GLP-1在体主要经过肾排泄和二肽酶Ⅳ(DPP—IV)降解来代谢。GLP-1的生物半衰期较短,约1—1.5分,很快被DDV—Ⅳ降解,因此,临床上很难检测其在血液中的浓度。
出处 《糖尿病新世界》 2010年第3期22-22,共1页 Diabetes New World Magazine
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同被引文献28

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