摘要
目的：观察肌松药顺式阿曲库铵对大鼠骨骼肌复合动作电位（CMAP）的影响。方法：32只大鼠随机分为2组，每组16只。实验组腹腔内注射顺式阿曲库铵（0．2mg／kg），对照组腹腔内注射等体积等渗生理盐水。于用药前及用药后每隔5min，刺激坐骨神经，于股二头肌记录CMAP，观察肌松药作用下CMAP潜伏期、波幅的变化规律。结果：2组间CMAP的潜伏期及波幅比较，差异均有统计学意义（潜伏期：F组间=8．654，P=0．010；F时间=6．753，P=0．030；波幅：F组间=6．634，P=0．030；F时间=7．134，P=0．020）。实验组CMAP变化可分为3个阶段：诱导期，表现为潜伏期逐渐延长，波幅逐渐下降，但与用药前相比，波幅下降幅度〈50％，该期持续15—20min；抑制期，表现为潜伏期逐渐延长，CMAP波形消失或波幅下降，幅度〉50％，该期持续10～15min；恢复期，表现为潜伏期逐渐缩短，波幅逐渐增高，直至恢复用药前水平，该期持续20—25min。结论：顺式阿陆库铵对CMAP的影响可分为诱导期、抑制期和恢复期3个阶段。为正确评价神经肌肉功能状况，术中肌电检测时应争取在恢复期（用药后40～45min）后进行。
Aim： To study the effects of cisatracurium on compound muscle action potential（CMAP） in rats. Meth- ods ：A total of 32 SD rats were divided into two groups. In the experiment group, cisatracurium （0.2 mg/kg）was given by intraperitoneal injection ,and isotonic saline of the same volume was given to the control group. CMAP was recorded in the biceps following a stimulation at the sciatic nerve at different time, i.e. every 5 minutes before and after injection until it returned to normal. Latency and amplitude of CMAP were calculated and statistically analyzed. Results：There were signifi- cant differences in CMAP latency and amplitude between two groups （CMAP latency：Fs,ouP = 8. 654, P = 0. 010; F,~.e = 6. 753 ,P = 0. 030 ; CMAP amplitude ： Fgroup = 6. 634, P = 0. 030 ; F,~ = 7.134, P = 0. 020 ）. As to the experiment group, the changes of CMAP were divided into 3 stages. Induction stage： the latency was gradually delayed, and the amplitude re- duced. But compared with normal CMAP,the amplitude reduction rate was below 50%. The stage lasted 15 ~ 20 minutes. Inhibition stage： CMAP was absent or the amplitude reduction rate was above 50%. The stage lasted 10 - 15 minutes. Res- toration stage：the latency was gradually shortened. However, the amplitude increased to normal state. The stage lasted 20 ~ 25 minutes. Conclusion ： The changes of CMAP under the effects of cisatracurium could be divided into induction, in- hibition,and restoration stage. In order to correctly evaluate the function of neuromuscle, the intraoperative CMAP test should be performed after restoration stage （40 -45 minutes after administration）.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2010年第2期275-277,共3页
Journal of Zhengzhou University(Medical Sciences)
