摘要
目的为明确维甲酸硅油（ＲＡ）对人类增生性玻璃体视网膜病变（ＰＶＲ）的作用寻求一种能有效防治ＰＶＲ的手段。方法将眼底情况相近的４０名患者４０眼分成２组；其中连续入选的２０眼，术中注入含５μｇ／ｍｌ、１０μｇ／ｍｌ维甲酸的硅油，另２０眼作为对照。结果经过２～６个月的随访，实验组与对照组在视网膜复位率和视功能方面无显著差异；实验组的增生复发率低于对照组，Ｐ＝０．０５。结论实验证实了维甲酸硅油能抑制玻璃体切割术后ＰＶＲ的复发。
ObjectiveTo evaluate the ability of retinoic acid(RA) in silicone oil to inhibit proliferative vitreoretinopathy.MethodsForty eyes of forty patients with severe PVR were treated.After the same surgical procedure was performed by the same surgeon,RA in silicone(5 μg/ml,10 μg/ml) was injected into 20 sequential eyes,which was the trial group.The other 20 eyes were administered silicone oil without RA as the control group.ResultsAfter 2～8 mon follow up,the retinal attachment and visual state of the two groups showed no difference,but the trial group had a lower recurrent rate of PVR than the control ( P =0.05).ConclusionDespite the small sample size,RA in silicone oil seems to decrease the recurrent rate of PVR after vitreous surgery.
出处
《眼科研究》
CSCD
1998年第4期312-314,共3页
Chinese Ophthalmic Research
基金
国家教委博士点课题
