摘要
目的:探讨血浆B型钠尿肽(brain natriuretic peptide,BNP)、单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平对不稳定型心绞痛(unstable angina,UA)近期预后判断的价值。方法:按Braunwald标准,85例心功能正常的UA患者分为ⅠB组(25例)、ⅡB组(30例)及ⅢB组(30例),并取20例稳定型心绞痛(SAP)患者作为对照组。入院后24h内抽肘前静脉血,分别行BNP和MCP-1检测。随访30天内主要不良心脏事件(MACE)。结果:UA组BNP及MCP-1均显著高于对照组(P均<0.05);ⅢB组显著高于ⅠB组和ⅡB组(P均<0.05)。冠状动脉3支与2支病变组BNP明显高于单支病变组(P均<0.05);3支病变组MCP-1明显高于2支及单支病变组(P均<0.05)。Logistic回归分析显示BNP和MCP-1是30天MACE的独立预测因素。结论:血浆BNP、MCP-1水平对心功能正常的UA近期不良预后的评估具有重要意义。
Objective：To evaluate the early prognostic role of plasma brain natriuretic peptide（BNP）and monocyte chemoattractant protein-1（MCP-1）levels in patients with unstable angina（UA）. Methods：Eighty-five cases UA without heart failure were divided into IB （n=25）,IIB（n=30）and IIIB（n=30）groups according to Braunwald classification, and 20 cases stable angina pectoris（SAP）were chosen in the control group. Plasma samples for BNP and MCP-1 were obtained in the first 24 h. The incidences of main abnormal cardiac event （MACE）were recorded during 30 days. Results：In every UA groups,plasma levels of BNP and MCP-1 elevated significantly, and in comparison to those in the control group,there were statistically significant difference（all P〈0.05）. Plasma levels of BNP and MCP-1 in IIIB group were higher than those in IIB group and IB group （all P〈0.05）. The levels of BNP and MCP-1 were significantly higher in patients who had complex lesions compared with those who had simple lesions （P〈0.05）. Multivariable logistic regression analysis revealed that BNP and MCP-1 were all risk factors for cardiac events （all P〈0.05）. Conclusion：Measurement of BNP and MCP-1 are helpful in predicting the short-term prognosis in UA patients without heart failure.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第3期405-408,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省"六大高峰人才"基金资助项目(2006075)
关键词
UA
BNP
MCP-1
预后
unstable angina（UA）
brain natriuretic peptide（BNP）
monocyte chemoattractant protein-1 （MCP-1）
prognosis
