摘要
动脉粥样硬化(atherosclerosis,AS)是严重威胁人类身体健康的疾病,临床资料表明,动脉粥样硬化好发于动脉开口、分叉和弯曲的部位,说明血流动力学在动脉粥样硬化的形成过程中起了重要作用。多项研究表明,不合适的血流剪切力会通过一系列的机制影响血管内皮细胞重构、增殖及凋亡,促进单核/巨噬细胞游走至血管弹力层,形成平滑肌细胞并病理性增殖,促进低密度脂蛋白(LDL)在血管内皮的沉积等等,从而在动脉粥样硬化的发生、发展及演变中起了极其重要的作用。
Atherosclerosis is a dangerous disease to human being. Clinical data show that atherosclerosis is inclined to dwell on the opening position, bifurcate and curve parts of the artery, which indicates that hematodynamics plays an important role in the process of atherosclerosis. Thousands of researches have revealed that the unsuitable blood flow shear stress can influence vascular endothelial cell reconstruction, generation and apoptosis as well,hasten monocaryon/macrophage migrating to the elastic layer of artery to form smooth muscle cells with pathological proliferation and then promote the deposition of the low-density lipoprotein （LDL） in vascular endothelium, which plays an extremely important role in the formation, development and evolution of atherosclerosis.
出处
《中国现代医生》
2010年第9期13-14,47,共3页
China Modern Doctor
关键词
动脉粥样硬化
血流剪切力
基因
炎症
Atherosclerosis
Blood flow shearing force
Gene
Inflammation.
