摘要
为探讨降压药对高血压患者心血管事件的影响。对１９９１年经高血压流行病学调查组确诊的高血压患者９７２例随访，实调人数８８５例，将其分为服药组和对照组，事件并发症组和无并发症组进行分析，并探讨降压药种类与心血管事件的关系。结果：高血压治疗组心血管事件并发症明显多于对照组（Ｐ＜００５），降压药中以复方降压片相对危险性最高（ＲＲ＝１．０），血管转换酶抑制剂（ＡＣＥＩ）的ＲＲ值最低（０１９），除钙拮抗剂（ＲＲ＝０．８９）外，凡与复方降压片联用者其ＲＲ值均升高。提示：钙拮抗剂、ＡＣＥＩ可作为治疗高血压的一线用药。
hypertensive patients who were diagnosed in the hypertensive epidemic investigation in 1991 have been followed up,but only 885 patients were actually investigated.They were divided into treated group and untreated group,in order to analyze the relationship between antihypertensive drugs and cardiovescular event.The results showed that there were more cardiovescular events in the treated group than in the untreated group ( P <0.05).The relative risk of Compound Reserpine Tablets was the highest( RR =1.0) and the relative risk of angiotensin converting enzyme inhibitors (ACEI) was the lowest( RR = 0.19) among antihypertensive drugs.When antihypertensive drugs,except calcium channel blocker,were combined with Compound Reserpine Tablets,their RR were all elevated.It is concluded that calcium channel blockers,β blockers and ACEI can be used as the first line drugs in the treatment of hypertension,but Compound Reserpine Tablets should be taken less or stop being taken.
出处
《河南医科大学学报》
1998年第4期64-67,共4页
Journal of Henan Medical University
基金
开封市科技攻关资助
