摘要
肝细胞分离技术日趋成熟,肝细胞移植成为较热门的研究领域,但供体短缺和免疫排斥反应,制约了其广泛应用。肝细胞微囊化有助于为肝细胞移植的推广应用提供大量的具有高度活性和良好功能的肝细胞。文章就肝细胞微囊化技术及其应用进展进行综述,为肝细胞大规模、高活性体外培养及长期冻存提供了新的途径。
With the development of cell separation technique,hepatocyte transplantation becomes a hot topic;however,the application is limited by donor deficiency and immunological rejection.Microencapsulated hepatocytes contribute to the promotion and application for liver cell transplantation,for which provide a large amount of high activity and good function of liver cells.In this paper,liver cell microencapsulation technology and its progress in applications were reviewed,providing prospective way for large-scale and high-active culture in vitro and long-term cryopreservation.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第3期549-551,共3页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家"十一五"高新技术研究发展计划-"863"项目(2008AA02Z417)
上海市科委自然科学基金(07ZR14076)
国家自然科学基金重点项目(20434030)
国家自然科学基金(30672043
30772105
20074031
30801107)
上海市教委科研创新项目(09YZ84)~~
