摘要
米非司酮是一种合成类固醇，具有抗孕酮、抗糖皮质激素和轻度抗雄激素特性，其对子宫内膜孕激素受体的亲和力比孕酮高5倍，具有终止早孕、促宫颈成熟等作用。随着对米非司酮作用机制及临床应用的深入研究，其应用范围不断扩大，在终止中期妊娠、晚期妊娠引产、稽留流产和死胎的引产、避孕、宫腔操作前预处理以及对子宫肌瘤、子宫内膜异位症、功能性子宫出血、异位妊娠的治疗等方面均有应用，并取得了较好的临床效果。该文就其在临床的具体效用及应用经验作以综述。
Mifepristone is a synthetic steroid. It exerts effects of antiprogesterone, antiglucocorticoid and weak effect of antiandrogen. It can terminate early pregnancy and promote cervical ripening because its affinity to endometrial progesterone receptor is five times higher than progesterone. With deepening in study on its mechanism and application in clinic, the application range of mifepristone has been extended continuously, for example, it has been also applied in termination of midtrimester of pregnancy, induction of labor in late pregnancy, missed abortion and stillbirth, contraception,pretreatment before operation in uterine cavity, and treatment of hysteromyomas, endometriosis, dysfunctional uterine bleeding（DUB）, ectopic pregnancy and so on.
出处
《中国妇幼健康研究》
2010年第2期256-258,共3页
Chinese Journal of Woman and Child Health Research
关键词
米非司酮
妇产科
临床应用
临床进展
mifepristone
obstetrics and gynecology
clinical application
progress in clinical study
