摘要
目的探讨涎腺导管癌中血管内皮生长因子(VEGF)、癌基因C-erbB-2及巨囊性病液体蛋白(GCDFP-15)的表达及意义。方法用免疫组化方法检测涎腺导管癌组织中VEGF、C-erbB-2及GCDFP-15的表达情况,以涎腺多形性腺瘤和涎腺囊肿作对照。结果涎腺导管癌中VEGF、C-erbB-2及GCDFP-15均100%阳性表达,VEGF、C-erbB-2及GCDFP-15在涎腺多形性腺瘤中的阳性表达率分别为80%、70%、0%,在涎腺囊肿中的表达分别为40%、0%、0%。三者差异有显著性(P<0.05)。结论VEGF、C-erbB-2在涎腺导管癌的发生、发展中起重要作用,GCDFP-15和C-erbB-2可作为涎腺导管癌的病理学诊断的一个重要标志物。
Objective To investigate the expression of VEGF,C-erbB-2 and GCDFP-15 in salivery duct carcinoma（SDC） and their clinical significance.Methods Immunohistochemical staining was used to detect the expression of VEGF,C-erbB-2 and GCDFP-15 in SDC by contrast with both pleomorphic adenoma of salivary gland and sialocele.Results Immunohistochemical staining for expression VEGF,C-erbB-2 and GCDFP-15 was carried out in all SDC,while 80%,70% and 0% in pleomorphic adenoma of salivary gland and 40%,0% and 0% in sialocele respectively.There was a statistical significance among those（P〈0.05）.Conclusion VEGF might play an important role in carcinogenesis and development in SDC,C-erbB-2 and GCDFP-15 might be used as markers for pathological diagnosis of SDC.
出处
《现代口腔医学杂志》
CAS
CSCD
2010年第2期128-130,共3页
Journal of Modern Stomatology
基金
云南省科技厅-昆明医学院应用基础研究联合专项资金项目(2007C0030R)
