摘要
目的研究丙泊酚复合咪唑安定和/或芬太尼用于胆道镜操作过程中的镇静效果。方法选择18-65岁行胆道镜的患者90例,随机分为三组：PF组（n=31）,首次静注芬太尼0.05 mg＋丙泊酚1 mg/kg;PM组（n=29）,首次静注咪唑安定2 mg＋丙泊酚1 mg/kg;PMF组（n=30）,首次静注芬太尼0.05 mg＋咪唑安定2 mg＋丙泊酚1 mg/kg。各组根据需要追加丙泊酚每次20-30 mg。记录心率、血压、脉搏血氧饱和度、镇静分级,观察患者症状及记忆缺失情况。结果用药后1 min三组患者都能达到满意的镇静效果（镇静分级2-3级）;所有患者停药后17 min完全清醒,PF组恢复时间最短（P〈0.01）,但有21例（67.7%）对操作过程有记忆,只有15例（48.4%）患者对麻醉镇静的方法感到很满意。结论丙泊酚复合咪唑安定和/或芬太尼在胆道镜操作中镇静效果更好,无明显不良反应。
Objective To study the sedation efficacy of propofol combined with midazolam and /or fentanyl in fibreoptic choledochoscope.Methods Ninty outpatients were randomly divided into three groups.Group PF（n=31）was given fentanyl 0.05 mg plus propofol 1 mg/kg intravenously,group PM（n=29） midazolam 2 mg plus propofol 1 mg/kg,and group PMF（n=30） fentanyl 0.05 mg,midazolam 2 mg and propofol 1 mg/kg.Propofol 20 mg was used when needed.HR,MAP,SpO2,sedation scores and amnesia were recorded.Results All patients were awakened in 20 minutes after procedures.The recovery time was shorter in group PF than that in the other two groups.There were 21（67.7%） patients in group PF,who were aware of surgery.Fifteen（48.4%） patients were satisfied in group PF.Conclusion Propofol combined with midazolam and /or fentanyl in fibreoptic choledochoscope has better sedation without any obvious side effects.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第1期19-20,共2页
Journal of Clinical Anesthesiology
