摘要
目的:探讨ω-3多不饱和脂肪酸对胃癌术后病人凝血功能和肠蠕动的影响及其可能机制。方法:将64例胃癌术后病人分为3组:传统补液营养组(A组,n=20)、肠外营养(parenteral nutrition,PN)和肠内营养(enteral nutrition,EN)组(B组,n=21)、EN和PN加ω-3多不饱和脂肪酸组(C组,n=23)。监测各组病人术后第6天凝血功能和肛门排气时间及术后半小时、第4天和第6天的超氧化物歧化酶(SOD)。结果:术后第6天C组纤维蛋白原(Fbg)与A组、B组相比增高(分别为P<0.05,P<0.01);C组病人SOD数值与A、B组相比下降趋势趋缓;C组病人排气时间要比A组和B组病人短(分别为P<0.05,P<0.05)。结论:术后应用ω-3脂肪酸对凝血功能的作用机制可能是通过纤维蛋白原及抗氧化系统发挥作用;ω-3脂肪酸可能有助于保护胃癌术后病人的抗氧化系统,有利于促进肠蠕动恢复。
Objective：To explor and investigate the effect and the possible mechanism of ω-3 polyunsaturated fatty acids（ω-3 PUFA） on coagulation and peristalsis in postoperative patients with gastric carcinoma.Methods：Sixty-four patients were divided into three groups：traditional fluid replacement,（group A,n =20）,parenteral nutrition withoutω-3 PUFA（group B,n =21）and PN adding ω-3 PUFA combined with enteral nutrition（group C,n =23）.Coagulation function in patients of each group on the sixth day,superoxide dismutase（SOD）at half an hour and on the forth,sixth day after operation was detectedw,hile the time of patients’anal exhaust gas was recorded.Results：The fibrinogen of the group C was increased on the sixth day compared to the group A and B（P 0.05,P 0.01）;the SOD trends increased in the group C compare to the group A,B;time of anal exhaust gas in group C was shorter than that in group A and B（P 0.05,P 0.05.） Conclusion：The mechanism of ω-3 PUFA for coagulation is uncertainb,ut may be through fibrinogen and antioxidant system;ω-3 PUFA maybe protect the antioxidant system;it can be beneficial to recover peristalsis.
出处
《温州医学院学报》
CAS
2010年第1期16-18,共3页
Journal of Wenzhou Medical College
基金
温州市科技局科技计划基金资助项目(Y20060298)
浙江省卫生厅重点扶植学科临床营养学资助项目
