摘要
目的:研究IL-18基因编码区105位点多态性与冠心病遗传易感性的关系。方法:采用多聚酶链反应限制性片段长度多态性分析法检测162例冠心病患者和134例对照者IL-18基因编码区105位点基因型,分析其与冠心病易感性的关系。结果:IL-18基因编码区105位点多态性中AA、AC、CC3种基因型在冠心病组和对照组中的频率分别为70.4%、29.0%、0.6%和88.1%、11.9%、0%。AC基因型患者患冠心病风险为AA基因型者的3.041倍(95%CI1.631～5.669),C等位基因携带者发生冠心病的风险是A等位基因携带者的2.806倍(95%CI1.556～5.061)(均P<0.01)。结论:IL-18基因编码区105位点多态性与福建地区部分汉族人群冠心病的发生存在相关性,携带AC、CC基因型人群发生冠心病风险较高。
Objective：To investigate the association of interleukin-18 gene 105 genetic polymorphism in the coding region with susceptibility to coronary heart disease （CHD）.Methods：IL-18 gene 105 genotypes in 162 CHD patients and 134 controls were detected using PCR-restriction fragment length polymorphism（RFLP） assay,and the association of genetic polymorphism with susceptibility to CHD was analyzed. Results：The frequencies of A/A,A/C,C/C types of interleukin-18 gene 105 polymorphism in CHD patients and controls were 70.4%,29.0% and 0.6%vs 88.1%,11.9% and 0%. Compared with AA genotype,the relative risk for CHD in people with AC genotype was 3.041（95% confidence interval [CI] 1.631-5.669）. The relative risk for CHD in people with C allele was 2.806 higher than people with A allele（95%CI 1.556-5.061）（P〈0.01）. Conclusions：IL-18 gene 105 genetic polymorphism is associated with CHD in Han nationality of Fujian province,people with AC or CC genotypes take higher risk of suffering from CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2010年第1期15-18,共4页
Journal of Clinical Cardiology
关键词
冠心病
白细胞介素-18
基因多态
coronary heart disease
interleukin-18
gene polymorphism
