摘要
目的:观察二甲双胍联合克罗米芬在治疗有胰岛素抵抗多囊卵巢综合征性不孕症的疗效。方法:选择2004年7月至2008年6月存在胰岛素抵抗的PCOS患者50例,将其随机分为两组,治疗组口服二甲双胍联合克罗米芬治疗6个月,对照组单纯口服克罗米芬治疗6个月,比较2组于用药3个月末、6个月末血总睾酮(T)、空腹血胰岛素(FINS)、排卵率、妊娠率的变化情况。结果:于用药3个月末、6个月末:T和FINS与治疗前比较:治疗组有明显的下降(P<0.05),对照组无明显变化(P>0.05);排卵率和妊娠率治疗组与对照组比较有明显差异(P<0.05)。结论:二甲双胍联合克罗米芬是目前治疗有胰岛素抵抗多囊卵巢综合征性不孕症的有效方法。
Objective：To observe the clinical effect of metformin combined with clomifene citrate in treatment of insulin resistance PCOS barrenness.Method：Choosing 50 PCOS patients who had insulin resistance from July 2004 to June 2008. Dividing these patients into 2 groups at random. The observation group takes metformin and clomifene citrate for 6 months. While the control group only takes clomifene citrate for 6 months. Compared the serum total testosterone （T）, fasting blood insulin（FIN）, ovulation rate and pregnancy rate of these two groups of patients after taking medicines after 3 months and 6 months. Result：After 3 months and 6 months, the T and FINS of observation group has decreased obviously（P0.05）, comparing to the situation before treatment; while the patients of control group has not change obviously（P0.05）. There is marked difference between them on ovulation rate and pregnancy rate（P0.05）.Conclusion：It is very efficient to use metformin combined with clomifene citrate in the treatment of insulin resistance PCOS barrenness at present.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2010年第3期567-569,共3页
Chinese Journal of Pharmaceutical Analysis
